茵栀黄颗粒治疗新生儿病理性黄疸

Yinzhihuang granules in the treatment of neonatal pathologic jaundice

目的观察茵栀黄颗粒治疗新生儿病理性黄疸的临床价值。方法选取150例新生儿病理性黄疸患儿,随机分为2组,每组各75例。对照组采用常规西医疗法进行治疗,在对照组治疗的基础上观察组配合使用茵栀黄颗粒,观察2组胆红素及皮肤黄疸的消退情况。结果治疗后2组胆红素水平比治疗前均有明显下降(P<0.001),观察组胆红素水平明显低于对照组(P<0.001);观察组黄疸消退时间明显短于对照组(P<0.001);对照组显效39例,有效21例,无效15例,观察组显效60例,有效15例,无效0例,观察组总有效率为100%,明显高于对照组(80.00%)(P<0.001)。在治疗期间2组均出现部分轻度腹泻患儿,每日解稀水便或少量稀便3~5次。其中对照组20例(26.67%),观察组11例(14.67%)。使用四联活菌和蒙脱石散综合治疗后好转。结论应用茵栀黄颗粒治疗新生儿病理性黄疸可以降低血清总胆红素水平,加速黄疸消退,明显改善临床症状。

Objective To observe the clinical value of Yinzhihuang granules in the treatment of neonatal pathological jaundice. Methods 150 children of neonatal jaundice were randomly divided into two groups, 75 cases in each group. The control group used conventional western medicine to treat; based on the control group, the observation group treated with Yinzhihuang granules, observe the bilirubin and jaundice subsided in two groups. Results After treatment, serum bilirubin levels of the observation group and the control group than before treatment were significantly decreased（P〈0.001）; After treatment, bilirubin level of the observation group was significantly lower than that of the control group（P〈0.001）. The time of jaundice extinction in observation group was significantly shorter than that in control group（P〈0.001）. The control group was markedly effective in 39 cases, effective in 21 cases, ineffective in 15 cases, the observation group was markedly effective in 60 cases, effective in 15 cases, ineffective in 0 cases. The total effective rate of the observation group was 100%, significantly higher than that of the control group 80%（P〈0.001）. In the treatment period, the observation group and the control group have mild diarrhea in children, daily diluted water or a small amount of sparse stool 3～5 times. Among them, 20 cases in the control group（26.67%）, 11 cases in the observation group（14.67%）. After using Tetravaccine and Montmorillonite powder improved after the treatment. Conclusions Application of Yinzhihuang granules in treatment of neonatal pathological jaundice significantly and the side effect is small.