围刺联合加巴喷丁治疗带状疱疹后遗神经痛的临床研究

Clinical Study of Surround Needling Combined with Gabapentin Treating PHN

目的:观察围刺联合加巴喷丁治疗带状疱疹后遗神经痛的临床疗效。方法:随机将门诊80例带状疱疹后遗神经痛患者分为对照组和治疗组,每组各40例。对照组给予口服加巴喷丁治疗,治疗组在加巴喷丁口服的基础上联合围刺治疗,疗程均为6周。对两组治疗前及治疗3、6周后的疼痛VAS评分、持续睡眠时间、SF-36评分进行比较,对治疗后两组临床疗效及不良反应发生情况进行比较。结果:治疗前两组VAS评分、持续睡眠时间、SF-36评分等各项指标比较,差异均无统计学意义(P>0. 05);治疗3、6周后,治疗组和对照组的上述指标均较治疗前明显改善(P <0. 05),但治疗组改善情况更加明显(P <0. 05)。治疗组总有效率高于对照组(P <0. 05)。两组不良反应均较轻微,以眩晕、嗜睡、共济失调为主,均未行特殊处理后自愈。结论:对带状疱疹后遗神经痛患者采用围刺联合加巴喷丁的方法进行治疗后,患者的疼痛症状、睡眠及生活质量均得到显著改善。该联合方法具有显著的疗效,且不良反应少,在临床上值得推广应用。

Objective： To investigate the clinical effect of surround needling combined with Gabapentin in the treatment of postherpetic neuralgia（ PHN）. Methods： A total of 80 patients with PHN were randomly divided into the control group（ n = 40） and the treatment group（ n = 40）. The control group was treated with Gabapentin;on which basis,the treatment group was also treated with surround needling. The course of the treatment was 6 weeks. VAS score,continuous sleep time and SF-36 scores were compared before and after 3 and 6 weeks of treatments in the two groups,and the clinical efficacy and adverse reactions were observed and compared between the two groups. Results： There were no significant differences in VAS score,continuous sleep time and SF-36 scores between the two groups before the treatment（ P〈0. 05）. After 3 and 6 weeks of treatments,the above indexes were significantly improved in the two groups（ P〈0. 05）; in which the treatment group improved more（ P〈0. 05）. The total efficacy rate in the treatment group were higher than that in the control group（ P〈0. 05）. Only mild adverse reactions,such as vertigo,lethargy,and ataxia were seen in the two groups; all of them recovered without special treatment. Conclusion： Surround needling combined with Gabapentin is effective in treating PHN with less adverse reactions,which can relieve pain,improve sleep quality and life quality,therefore it is worthy of clinical application.