血清PSA、T、DHEAS诊断多囊卵巢综合征临床价值

The value of serum PSA,T and DHEAS levels for diagnosing of polycystic ovary syndrome

目的:分析血清前列腺素特异抗原(PSA)、睾酮(T)、硫酸脱氢表雄酮(DHEAS)在多囊卵巢综合征诊断价值。方法:回顾性收集2015年6月—2017年12月本院收治的多囊卵巢综合征患者159例为观察组,选择同期临床体检89例为对照组。比较两组血清PSA、T、DHEAS水平,观察组治疗前后血清PSA、T、DHEAS水平变化,分析各血清指标间的相关性及诊断效能。结果:观察组血清PSA、T及DHEAS水平均高于对照组,且治疗后低于治疗前(P<0.05)。观察组血清PSA、T及DHEAS均呈相关性。PAS曲线下面积为0689,敏感度及特异度分别为0.768和0.550;T曲线下面积为0.812,敏感度及特异度分别为0.783和0.737;DHEAS曲线下面积为0.760,敏感度和特异度分别为0.522和0.900,联合检测曲线下面积为0.886,敏感度及特异度分别为0.768和0.875,联合检测曲线下面积明显高于单个指标。结论:血清PSA、T、DHEAS可作为多囊卵巢综合征雄激素增高的标志物,联合检测能够提高疾病的诊断效能。

Objective： To analyze the value of serum prostaglandin specific antigen （PSA）, testosterone （T） and DHEAS for diagnosing women with polycystic ovary syndrome （PCOS）. Methods： 158 women with PCOS who had treated in hospital affiliated to Xuzhou medical university from June 2015 to December 2017 were in study group, and during the same period, 89 healthy women from who had accepted physical examination were selected into control group. The serum PSA, T and DHEAS levels of all women in both group were compared, and the serum PSA, T and DHEAS levels of women in study group were compared before and after treatment. The correlations among the serum serum PSA, T and DHEAS levels and their diagnostic efficacy were analyzed. Results： The serum PSA, T and DHEAS levels of women in study group were significant higher than those of women in control group （ P 〈0.05）. In study group, the serum PSA, T and DHEAS levels of women before treatment were significant lower than those after treatment （P〈0.05）. Serum PSA, T and DHEAS levels were correlated in study group. The area under PAS curve was 0.689, and the sensitivity and specificity was 0.768 and 0.550, respectively. The area under T curve was 0.812, and the sensitivity and specificity was 0.783 and 0.737, respectively. The DHEAS area under the curve was 0.760, sensitive and specific degree was 0.522 and 0.900, respectively. The joint detection area under the curve was 0.886, which was significant higher than that of individual indicator, and sensitivity and specificity was 0.768 and 0.875, respectively. Conclusion： The levels of serum PSA, T and DHEAS detected can be used as the markers of androgen increasing of women with PCOS, and the combined detected level of serum PSA, T and DHEAS can increase the diagnosis efficiency of PCOS.