孕11～13^(+6)周眼动脉和螺旋动脉多普勒参数对子痫前期的预测价值

Ophthalmic and uterine spiral artery Doppler prediction of preeclampsia at 11-13+6 weeks' gestation

目的探讨孕11～13^(+6)周孕妇眼动脉和子宫螺旋动脉多普勒参数对子痫前期的预测价值。方法选取2016年6月至2018年2月在本院行11～13+6周NT超声筛查的孕妇500例,根据妊娠结果分为正常组和子痫前期组,所有孕妇在11～13+6周均检测眼动脉和子宫螺旋动脉的RI(阻力指数)、PI(搏动指数)、眼动脉PD1(舒张期第一峰值流速)、PSV(收缩期峰值血流)、PR(峰值流速比值,PD1/PSV)。结果子痫前期组孕妇眼动脉PD1、PR和子宫螺旋动脉RI较正常组升高(P<0.05),差异有统计学意义。子痫前期孕妇眼动脉PI和RI较正常组降低,子宫螺旋动脉PI高于正常组,但差异无统计学意义(P>0.05)。结论孕11～13+6周孕妇眼动脉PD1、PR和子宫螺旋动脉PI可用于子痫前期的早期预测。

Objective To determine the accuracy of ophthalmic and spiral artery Doppler at 11-13^6 weeks＇ gestation for the prediction of preeclampsia. Method Maternal ophthalmic and artery Doppler signals were recorded in 500 singleton pregnancies at 11-13^6 weeks＇ gestation. Pulsatility and resistance indices （PI, RI）, peak systolic velocity （PSV） ,first peak diastolic velocity （PDI） , and peak ratio （PR） were measured. Results Resistance index of uterine spiral artery , first peak diastolic velocity and peak ratio of ophthalmic artery were significantly higher in pregnant women with preeclampsia than in those with normal fetuses, with P〈0.05. Pulsatility index and resistance index of ophthalmic artery were lower in pregnant women with preeclampsia than in those with normal fetuses （P〉0. 05）. The pulsatility index of spiral artery was higher in the preeclampsia group than in the control group （P〉0.05）. Conclu-sions The combined analysis of ophthalmic and uterine spiral artery blood flow parameters of 11 - 13^6 weeks pregnant can be used for the early prediction of preeclampsia.