茵栀黄口服液治疗足月新生儿黄疸45例

Yinzhihuang Oral Liquid in Treating Full-term Neonatal Jaundice for 45 Cases

目的评价茵栀黄口服液治疗足月新生儿黄疸的临床疗效。方法收集2017年4月—2018年4月本院收治的90例足月新生儿黄疸患儿,按照入院顺序编号,随机分组,各45例,分别采用常规治疗以及在此基础上联合茵栀黄口服液。对比疗效、康复进程、指标改善情况以及预后指标。结果观察组整体疗效优于对照组,观察组愈显率高于对照组(P<0.05)。观察组黄染消退时间、伴随症状消失时间、总光疗时间、痊愈时间低于对照组,观察组3日后经皮检测胆红素与血清总胆红素下降幅度高于对照组,差异均有统计学意义(均P<0.05)。观察组与对照组转住院、并发症、强化治疗情况差异无统计学意义(P>0.05)。观察组不良反应发生率13.3%,高于对照组0.0%,差异有统计学意义(P<0.05)。结论茵栀黄口服液治疗足月新生儿黄疸可以增进疗效,但也存在不良反应,适合胃肠耐受较好的患儿。

Objective To evaluate the clinical observation of Yinzhihuang oral liquid in the treatment of term neonatal jaundice.Methods From April 2017, 90 newborns with jaundice were enrolled in the study group. By April 2018, 90 children were enrolled and randomly divided into two groups according to the order of inclusion, with 45 cases in the control group and 45 cases in the observation group. The control group adopted conventional treatment. The observation group was treated with routine treatment combined with Yinzhihuang oral liquid on the basis of the control group. Efficacy, rehabilitation progress, improvement of indicators and prognostic indicators were compared. Results The overall curative effect of the observation group was better than that of the control group, and the effective rate of the observation group was higher than that of the control group （P 〈 0.05）. The regression time of yellow dye, the time of accompanied symptoms disappearance, the time of total phototherapy and the time of cure were lower in the observation group than in the control group. The decrease of bilirubin and serum total bilirubin in the observation group was significantly higher than that in the control group after 3 days （P 〈 0.05）. There was no significant difference in hospitalization, complications and intensive treatment between the observation group and the control group （P 〉 0.05）. The incidence of adverse reactions in the observation group was 13.3%, which was significantly higher than 0% in the control group （P 〈 0.05）. Conclusion Yinzhihuang oral liquid can improve the curative effect of jaundice of full-term newborns, but there are also adverse reactions. It is necessary to grasp the indications and be suitable for those objects with better gastrointestinal tolerance.