不同浓度舒芬太尼配伍罗哌卡因在分娩镇痛中的应用效果

Effect of Different Concentrations of Sufentanil Compatibility of Ropivacaine in Labor Analgesia

目的探讨两种不同浓度舒芬太尼配伍罗哌卡因在分娩镇痛中的应用效果。方法选择于我院自愿要求行硬膜外分娩镇痛方案初产妇200名,采用随机双盲的方法,分为A组和B组,各100例。观察比较2组产妇疼痛(VAS)评分及不良反应发生情况。结果 B组孕产妇镇痛后5min、10min、30min、60min和90min的VAS评分显著低于A组孕产妇,差异有统计学意义(P<0.05)。2组给药后新生儿出生后1min、10min时Apgar评分比较,差异无统计学(P>0.05)。B组孕产妇恶心呕吐发生率比A组高,差异无统计学意义(P>0.05),但B组皮肤瘙痒、尿潴留发生率显著高于A组,差异有统计学意义(P<0.05)。结论 0.82μg/m L舒芬太尼比0.41μg/m L舒芬太尼起效较快,镇痛效果较好,但0.82μg/m L浓度的舒芬太尼会导致较高的不良反应发生率。

Objective To explore the effect of two different concentrations of sufentanil compatibility of ropivacaine in labor analgesia. Methods A total of 200 primiparas with epidural analgesia were selected in our hospital. They were randomly divided into group A and group B, with 100 cases in each group. The pain score（VAS） and the incidence of adverse reactions in 2 groups were observed and compared. Results The VAS scores of 5 min, 10 min, 30 min, 60 min and 90 min in group B were significantly lower than those in the group A（P〈0.05）. There was no significant difference in the Apgar scores between the 2 groups after the birth of 1 min and 10 min（P〉0.05）. The incidence of nausea and vomiting in group B was higher than that in group A（P〉0.05）, but the incidence of skin pruritus and retention of urine in group B was significantly higher than that in group A（P〈0.05）. Conclusion 0.82 μg/m L sufentanil has faster onset and better analgesic effect than sufentanil 0.41μg/m L sufentanil, but sufentanil with a concentration of 0.82 μg/m L can lead to a higher incidence of adverse reactions.