无锡地区CIN患者HPV基因型分布特点初步分析

Preliminary Analysis of Human Papilloma Virus(HPV) Subtypes Distribution Characteristics in CIN Patients in Wuxi Region

目的通过分析无锡妇女CIN患者HPV基因型分布特点,探讨HPV分型与CIN的相关性。方法统计分析我院门诊宫颈癌筛查妇女269例,年龄21~65岁(32.5±11.8岁),进行妇科检查、宫颈细胞学、HPV基因分型检查。结果 CIN患者HPV16患病构成比有显著性(P<0.05),30-50岁是HPV16感染的高峰期。HRHPV感染与CIN患者显著相关,优势比为16.69,HR-HPV感染是CIN患者一个重要的危险因素。CINⅠ病变与CINⅡ与CINⅢ组的各组间HPV16基因型感染率比较,差异具有统计学意义。结论探讨HPV分型与CIN的相关性,有助于临床患者宫颈的癌前病变早发现、早诊断及早治疗,降低患者宫颈癌的发病率及死亡率。

Objective To explore the correlation between HPV typing and CIN by analyzing the distribution characteristics of HPV genotypes in CIN patients in women in wuxi. Methods A total of 269 cases of cervical cancer screening women aged from 21 to 65（32.5 ＋ 11.8 years） were statistically analyzed, and gynecological examination, cervical cytology, and HPV genotyping were performed. Results The composition of HPV16 in CIN patients was significant（P〈 0.05）. Hr-hpv infection is significantly associated with CIN patients, with an advantage ratio of 16.69. Hr-hpv infection is an important risk factor for CIN patients. CIN Ⅰ lesions and CIN Ⅱ and CIN Ⅲ group of HPV16 genotype infection rate between groups, difference is statistically significant. Conclusion To explore the correlation between HPV typing and CIN is helpful for the early detection, early diagnosis and early treatment of cervical precancerous lesions in clinical patients, and to reduce the incidence and mortality of cervical cancer in patients.