rtA181V和rtA181T两种耐药模式的CHB患者血清HBsAg水平比较

Comparison of serum HBsAg level in CHB patients with rtA181V and rtA181T drug-resistant mutation

目的:比较rt A181V和rt A181T两种耐药模式的慢性乙型肝炎(CHB)患者血清HBsAg的水平。方法:回顾性分析徐州医科大学附属医院2015年9月至2017年10月之间就诊于感染科门诊及住院部,口服阿德福韦酯(ADV)单药治疗后发生rt A181V和rt A181T耐药变异的CHB患者共217例,其中rt A181V耐药模式111例,rt A181T耐药模式106例,比较两组患者血清HBsAg的含量。结果:rt A181T组血清HBsAg水平显著低于rt A181V组(P <0. 05)。结论:发生rt A181T耐药变异模式的CHB患者,血清HBsAg含量低于耐药模式为rt A181V的患者。

Objective： To compareserum HBsAg level in CHB patients with rt A181 T and rt A181 V drug-resistant mutation. Methods： 217 ADV treated patients were enrolled in our hospital from 2015 to 2017,including 111 rt A181 V mutationpatients and 106 rt A181 T mutation patients. Serum HBsAg of these two mutation groups was compared by retrospective comparison and analysis. Results： Serum HBsAg level of rt A181 T mutation was significantly lower than that in rt A181 V group（ P〈0. 05）. Conclusion： CHB patients with rt A181 T mutation have a lower expression of HBsAgthan rt A181 V mutation patients.