大黄蛰虫丸联合醋酸亮丙瑞林治疗子宫内膜异位症的临床研究

Effect of Dahuangzhechongwan pills combined with leuprorelin on endometriosis

目的:探讨大黄蛰虫丸联合醋酸亮丙瑞林治疗子宫内膜异位症的临床疗效。方法:选取我院收治的123例子宫内膜异位症腹腔镜术后患者作为研究对象,采用随机数字表法分为观察组、对照1组及对照2组,对照1组给予醋酸亮丙瑞林治疗,对照2组给予大黄蛰虫丸治疗,观察组则另口服给予大黄蛰虫丸联合醋酸亮丙瑞林治疗,所有患者均治疗28周。治疗结束后,评价3组患者疗效。治疗前及治疗28周后,观察3组患者生活质量评分,主要包括环境领域、社会关系领域、生理领域及生活领域评分。治疗前及治疗28周后,收集3组患者静脉血,检测其中性激素含量[黄体生成素(LH)、卵泡刺激素(FSH)及雌激素(E2)],子宫内膜异位症标记物含量[糖类抗原125(CA-125)、抗子宫内膜抗体(EMAb)及基质金属蛋白酶-3(MMP-3)]。治疗期间,密切观察患者的药物不良反应发生情况。结果:治疗后,观察组总有效率明显高于对照1组及对照2组(P <0. 05);治疗后,观察组环境领域、社会关系领域、生理领域及生活领域评分均明显高于对照1组及对照2组(P <0. 05);治疗后,观察组LH、FSH、E2、CA-125、EMAb及MMP-3均明显低于对照1组及对照2组(P <0. 05)。治疗期间,3组不良反应发生率基本一致(P> 0. 05)。结论:大黄蛰虫丸联合醋酸亮丙瑞林治疗子宫内膜异位症疗效确切,安全性较好,值得深入研究。

Objective： To explore the effect of dahuangzhechongwan pills combined with leuprorelin on endometriosis. Methods： 123 cases of endometriosis patients after laparoscopy in our hospital were divided into the control group 1（ 41 cases）,control group 2（ 41 cases） and observation group（ 41 cases）. The control group 1 was treated with leuprorelin,control group 2 was treated with dahuangzhechongwan pills and the observation group was given dahuangzhechongwan pills and leuprorelin. The treatment time was 28 weeks. Before and 28 weeks after the treatment,the living quality scores（ environmental scores,social scores,physical scores and life scores）,sex hormone content（ FSH,E2 and LH） and endometriosis markers content（ MMP-3,CA-125,EMAb） were observed in the 3 groups. During the treatment,the adverse actions were observed. Results： After the treatment,the total effective rate was significantly higher in the observation group than in the control group（ P〈0. 05）. After the treatment,the environmental scores,social scores,physical scores and life scores were significantly higher in the observation group than the control group 1 and the control group 2（ P〈0. 05）,while the levels of MMP-3,CA-125,EMAb,IgG,FSH,E2 and LH in the observation group were significantly lower than in the control group 1 and control group 2（ P〈0. 05）. During the treatment,the rate of adverse reactions were similar in the 3 groups（ P〉0. 05）. Conclusion： Dahuangzhechongwan pills combined with leuprorelin in the treatment of endometriosis has a good clinical curative effect and safety,worthy of further study.