尼可地尔对急性心肌梗死患者冠状动脉介入术后心功能及临床预后的影响

Effects of Nicorandil on Cardiac Function and Clinical Prognosis in Patients with Acute Myocardial Infarction after Coronary Intervention

目的探究尼可地尔对急性心肌梗死患者冠状动脉介入术后心功能及临床预后的影响。方法选择某院自2015年1月-2017年1月收治的142例行冠状动脉介入术治疗的急性心肌梗死患者作为研究对象,采用随机数字表法将患者分成对照组和研究组,每组71例,对照组仅给予常规性的辅助治疗,研究组在常规治疗的基础上增加尼可地尔治疗,比较两组患者术后即刻和治疗6个月后的心功能及临床预后情况。结果治疗6个月后,研究组患者的左室射血分数和心指数均明显高于对照组,术后30分钟、90分钟及150分钟,研究组患者的尿8-epi-PGF2α排泄率分别为59.8±1.3、57.5±1.4、60.4±1.2、62.5±1.4,均明显低于对照组;研究组患者术后心脏事件总发生率(8.5%)明显低于对照组(15.5%),两组对比差异显著。结论在急性心肌梗死患者行冠状动脉介入术期间采用尼可地尔辅助治疗,能有效抑制患者体内活性氧类物质生成和改善其心功能,从而降低术后的心脏事件的发生率。

Objectives To investigate the effect of nicorandil on cardiac function and clinical prognosis after coronary intervention in patients with acute myocardial infarction. Methods A total of 142 patients with acute myocardial infarction who underwent coronary intervention for treatment from January 2015 to January 2017 were selected as subjects. The patients were divided into a control group and a study group using a random number table method. In the control group,only routine adjuvant therapy was given. The study group was treated with nicorandil on the basis of conventional treatment. The cardiac function and clinical prognosis of the two groups after immediate and six months of treatment were compared. Results After 6 months of treatment,left ventricular ejection fraction and heart index were significantly higher in the study group than in the control group. Urinary 8-epi-PGF2α excretion rates in the study group were 59.8±1.3 at 30 min,90 min,and 150 min postoperatively,respectively.57.5±1.4,60.4±1.2,62.5±1.4,all significantly lower than the control group; the total incidence of postoperative cardiac events in the study group（8.5%） was significantly lower than that in the control group（15.5%）,and there was significant difference between the two groups. Conclusions Nephrodir adjuvant therapy in patients with acute myocardial infarction during coronary intervention could effectively inhibit the production of reactive oxygen species and improve their cardiac function,thereby reducing the incidence of postoperative cardiac events.