内消瘰疬丸治疗乳腺增生伴随相关结节性疾病的临床分析

Clinical Analysis of Endoscrofulofuric Pill in the Treatment of Breast Hyperplasia Associated with Nodular Disease

目的探讨内消瘰疬丸治疗乳腺增生伴随相关结节性疾病的临床疗效。方法选择2014年12月1日-2017年12月1日某院收治的200例乳腺增生伴随相关结节性疾病患者,随机分为对照组与治疗组,对照组施以口服百消丹治疗,实验组施以内消瘰疬丸口服治疗,观察临床治疗效果,计算单纯乳腺增生组患者ORR与CRR,乳腺增生并慢性结节组患者ORR比较、治疗前后的雌二醇(E_2)、催乳素(PRL)与孕酮(P)的变化。结果治疗前两组患者的E_2、PRL、P与单纯乳腺增生的两组患者的CRR、乳腺增生并子宫肌瘤患者的ORR无显著差异,不具有统计学意义。治疗后治疗组的E_2、PRL分别为204.27±35.89pmol/ml与12.49±1.58μg/L,明显低于对照组的261.48±53.15pmol/ml与19.83±2.37μg/L,临床治疗总有效率为98.33%,明显高于对照组的70.00%;单纯乳腺增生患者的ORR、乳腺增生并慢性淋巴结炎、乳腺增生并甲状腺结节患者的ORR明显高于对照组,差异具有统计学意义。结论内消瘰疬丸治疗乳腺增生伴随相关结节性疾病具有显著的临床效果,具有较高的临床推广价值。

Objecitve To investigate the clinical effect of endoscrofulofuric pill on the treatment of mammary gland hyperplasia associated with nodular disease. Methods From December 1st,2014 to December 1st,2017,200 cases of mammary gland hyperplasia patients treated in a hospital,with related nodular diseases were randomly divided into control group and treatment group and control group with oral Dan elimination treatment,the experimental group with inside disappear scrofula bolus oral therapy,observation group of patients clinical therapeutic effect,simple mammary gland ORR,CRR,hyperplasia of mammary glands and ORR comparison,before and after treatment in patients with chronic nodule group of estradiol（E2）,prolactin（PRL） and progesterone（P）. Results Before treatment,there was no significant difference in ORR between patients with CRR,mammary hyperplasia and uterine fibroids between E2,PRL,P and patients with simple mammary hyperplasia. After treatment,the treatment group of E2 and PRL were 204.27±35.89 pmol/ml and 12.49±1.58 mu g/L,significantly lower than the control group of 261.48±53.15 pmol/ml and 19.83±2.37 mu g/L,the clinical total effective rate was 98.33%,significantly higher than the control group 70.00%;ORR of patients with pure hyperplasia of mammary gland,with hyperplasia of mammary glands and chronic lymphadenitis,with hyperplasia of mammary glands and the thyroid nodule was obviously higher than that of control group,the difference was statistically significant. Conclusions The endoscrofulofuric pill had significant clinical effect in the treatment of mammary hyperplasia associated with nodular disease and had high clinical value.