药用植物硒多糖的研究进展

Recent research progress of selenium polysaccharides from medicinal plants

硒多糖是一种通过多糖与硒的结合且具备硒和多糖两者活性的有机硒化合物。硒多糖的生物活性普遍高于硒和多糖,且更易于被机体吸收和利用,因此硒多糖在免疫调节、抗肿瘤、抗氧化、抗衰老等方面具有广泛的应用。由于硒多糖独特的药理活性,药用植物硒多糖也因此逐渐成为研究热点。但是目前已发现的硒多糖种类较少,同时其多糖的结构十分复杂,对硒多糖化学结构以及体内作用机制尚不完全清楚,仍有待进一步的研究。该文系统的介绍了药用植物硒多糖的主要来源,以及已发现的药用植物硒多糖的主要结构及其生理活性,旨在为硒多糖的进一步研究和应用提供理论依据。

Selenium polysaccharides（Se polysaccharides） are a kind of organic selenium compounds which obtain the activities from Se and polysaccharides. Comparing to Se or polysaccharides,Se polysaccharides exhibit improved biological activities and are more prone to be absorbed by human bodies,therefore,they have been widely used in medical applications,such as immunomodulation,anti-tumor,anti-oxidation,anti-aging. Due to their unique pharmacological activities,Se polysaccharides from medicinal plants have gradually become a research hotspot. However,only a few of Se polysaccharides have been separated and purified in recent years.The structure of polysaccharides is also very complex,therefore,determination of the chemical structure and mechanism of bioactivity of Se polysaccharide in vivo remain to be further studied. This article systematically introduced the main source and biological activities of Se polysaccharides from medicinal plants. The purpose of this review is to provide a basis for the further research of Se polysaccharides.