补益宗气法治疗慢性阻塞性肺疾病稳定期疗效及对血清COX-2、MMP-9水平的影响

Effect of Replenishing Qi and Regulating Qi Therapy on COPD Stable Phase and Serum COX-2 and MMP-9 Levels

目的：探讨补益宗气法治疗慢性阻塞性肺疾病（COPD）稳定期的疗效及对血清环氧化酶-2（COX-2）、基质金属蛋白酶-9（MMP-9）水平的影响。方法：选取2014年6月—2017年3月医院收治的COPD稳定期患者122例,根据随机数字法分为对照组和观察组。对照组患者吸入可必特治疗,观察组在对照组治疗基础上联合补益宗气法治疗,分析两组患者治疗效果。结果：两组患者治疗后咳嗽、咳痰、气促、喘息评分均较治疗前下降,PEF、FEV1%及FVC水平均较治疗前上升,COX-2、PGE_2、MMP-9及TGF-β1水平均较治疗前下降（P 〈0. 05）。观察组患者治疗后临床症状评分、肺功能指标、COX-2、PGE2、MMP-9及TGF-β1水平均优于对照组（P 〈0. 05）。观察组患者治疗期间复发率低于对照组（P 〈0. 05）。结论：补益宗气法治疗COPD稳定期疗效确切,可改善临床症状和肺功能,降低血清COX-2、PGE2、MMP-9水平。

Objective：To investigate the effect of tonifying Qi and promoting Qi therapy on stable phase of chronic obstructive pulmonary disease（ COPD） and its influence on serum cyclooxygenase-2（ COX-2） and matrix metalloproteinase-9（ MMP-9） levels. Methods：A total of 122 stable COPD patients from June 2014 to March 2017 in our hospital were randomly divided into control group and observation group. The control group inhaled combivent in the treatment and the observation group combined tonifying Qi and promoting Qi treatment. We analyzed the therapeutic effect of two groups. Results：Two groups＇ cough,expectoration,shortness of breath and wheezing scores after treatment were lower than those before treatment. PEF,FEV1% and FVC levels increased. Compared with those before treatment,COX-2,PGE_2,MMP-9 and TGF-β1 levels were lower than those before treatment（ P〈0. 05）. After treatment,clinical symptoms were observed,lung function indexes COX-2,PGE2,MMP-9 and TGF-beta 1 were better than those of the control group（ P〈0. 05）. Patients＇ recurrence rate in the observation group during the treatment was lower than that of the control group（ P〈0. 05）. Conclusion：The effect of tonifying Qi and Qi therapy on COPD stable phase is exact,which can improve the clinical symptoms and pulmonary function,and reduce the serum levels of COX-2,PGE2 and MMP-9.