摘要
目的:提高五味安神颗粒的产品质量,优化制备工艺。方法:通过单因素试验优化颗粒的制备工艺,以辊压制粒后的干颗粒粒径分布为考核指标,对影响干压制粒的轧辊压力、轧辊转速和物料的传送速度进行考察。结果:优化后的干法制粒工艺中间体颗粒得率达到64%,工艺参数为螺旋转速120rpm,轧辊转速26rpm,轧辊间隙0.8mm,整粒转速150rpm,工作压力120bar,整粒孔径1.5mm。结论:干法制粒工艺制备的中间体颗粒符合质量要求。
Objective: To investigate the optimization of the preparation process for Wuwei Anshen granules and to improve its quality. Methods: A single-factor experiment was performed to optimize the preparation process for granules. With the distribution of the diameter of dry granules after rolling granulation as the evaluation index,the influencing factors for dry granulation were evaluated,including rolling pressure,rolling rotation speed,and material transfer speed. Results: The optimized dry granulation process achieved a yield of intermediate granules of 64%,with a spiral rotation speed of 120 rpm,a rolling rotation speed of 26 rpm,a rolling spacing of 0. 8 mm,a granulating rotation speed of 150 rpm,a working pressure of 120 bar,and a granular pore diameter of 1. 5 mm. Conclusion: Intermediate granules prepared by dry granulation process meet the quality requirements.
作者
黄生武
汤波
朱立华
HUANG Sheng-wu;TANG Bo;ZHU Li-hua(Hunan Kanerga Pharmaceutical Group,Changde 415900,Hunan,China;Hunan Academy of Chinese Medicine,Changsha 410013,Hunan,China)
出处
《湖南中医杂志》
2018年第9期173-175,共3页
Hunan Journal of Traditional Chinese Medicine
关键词
五味安神颗粒
湿法制粒
干法制粒
工艺优化
Wuwei Anshen granule
wet granulation
dry granulation
process optimization