益母草注射液联合米非司酮配合清宫术治疗胚胎停止发育的疗效观察

Clinical observation of Yimucao Injection combined with mifepristone and curettage in treatment of embryos stop developing

目的探究益母草注射液联合米非司酮配合清宫术治疗胚胎停止发育的临床疗效。方法选取2015年9月—2017年8月重庆市高新区人民医院收治的胚胎停止发育患者150例,随机分为米非司酮组、益母草组与联合组,每组各50例。米非司酮组患者术前连续2 d空腹口服米非司酮片,100 mg/次,1次/d,并于术中和术后注射缩宫素注射液。益母草组在术中孕囊吸出后给予益母草注射液2 m L和一定量缩宫素注射液,术后连续给予益母草注射液3 d,1 m L/d,同时给予缩宫素注射液。联合组患者同时给予米非司酮片和益母草注射液及缩宫素注射液,用法用量同米非司酮组和益母草组。观察3组患者临床疗效,同时比较治疗前后3组患者手术相关指标、绒毛膜促性腺激素(HCG)转阴情况和月经恢复时间。结果治疗后,联合组成功率100.00%,显著高于益母草组的88.00%,两组比较差异具有统计学意义(P<0.05)。治疗后,益母草组失血量和阴道流血时间显著少于米非司酮组(P<0.05),联合组在手术时间、术中缩宫素用量、失血量及阴道流血时间上均明显少于米非司酮组和益母草组,与单用两组比较差异均具有统计学意义(P<0.05)。治疗2周内,联合组HCG转阴率显著高于米非司酮组和益母草组(P<0.05)。结论米非司酮联合益母草注射液配合清宫术治疗胚胎停止发育疗效显著,可缩短手术时间,提高清宫成功率,促进月经恢复。

Objective To explore the clinical efficacy of Yimucao Injection combined with mifepristone and curettage in treatment of embryos stop developing. Methods Patients（150 cases） with embryos stop developing in the People’s Hospital of Chongqing Gaoxin District from September 2015 to August 2017 were randomly divided into mifepristone group, Yimucao group and combined group, and each group had 50 cases. Patients in the mifepristone group were preoperatively po administered with Mifepristone Tablets for 2 d, 100 mg/time, once daily, and were intraoperatively and postoperatively iv administered with Oxytocin Injection. Patients in the Yimucao group were iv administered with Yimucao Injection 2 m L and certain amount Oxytocin Injection after the sucking of the gestation sac, and continuously given Yimucao Injection for 3 d after the surgery, 1 m L/d, at the same time they were given Oxytocin Injection. Patients in the combined group were given Mifepristone Tablets and Yimucao Injection, the usage and dosage were the same with the other groups. After treatment, the clinical efficacy was evaluated, and the surgery-related indexes, the HCG negative rate and menstrual recovery time in three groups before and after treatment were compared. Results After treatment, the success rate in the combined group was 100.00%, which was significantly higher than 88.00% in the Yimucao group, and there were differences between two groups（P 〈 0.05）. After treatment, the volume of blood loss and vaginal bleeding time in the Yimucao group was significantly less than that in the mifepristone group（P 〈 0.05）, and the duration of surgery, dosage of oxytocin during the surgery, volume of blood loss and vaginal bleeding time in the combined group after treatment was significantly less than that in the mifepristone group and Yimucao group, the difference is statistically significant compared with the other two groups（P 〈 0.05）. Within 2 weeks of treatment, HCG negative rate in the combined group was significantly higher than that in the mifepristone group and Yimucao group（P 〈 0.05）. Conclusion Yimucao Injection combined with mifepristone and curettage in treatment of embryos stop developing has obvious curative effect, can shorten the operation time, improve the uterine clearance success rate and promote the recovery of menstruation.