妇科千金胶囊联合替硝唑治疗慢性盆腔炎的临床研究

Clinical study on Fuke Qianjin Capsules combined with tinidazole in treatment of chronic pelvic inflammatory disease

目的研究妇科千金胶囊联合替硝唑氯化钠注射液治疗慢性盆腔炎的临床疗效。方法选取青海大学附属医院2015年5月—2017年5月收治的慢性盆腔炎患者120例作为研究对象,将所有患者随机分为对照组和治疗组,每组各60例。对照组静脉缓慢滴注替硝唑氯化钠注射液,0.8 g/次,1次/d。治疗组在对照组治疗基础上口服妇科千金胶囊,2粒/次,3次/d。两组患者连续治疗14 d。观察两组患者的临床疗效,比较两组治疗前后的临床症状缓解时间和血清细胞因子水平。结果治疗后,对照组和治疗组的总有效率分别为80.00%、95.00%,两组总有效率比较差异具有统计学意义(P<0.05)。治疗后,治疗组患者下腹部坠胀、疼痛状缓解时间和腰骶部酸痛缓解时间显著短于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者白细胞介素-4(IL-4)水平升高,超敏反应C蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)水平均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗后治疗组血清细胞因子改善程度显著优于对照组,两组比较差异具有统计学意义(P<0.05)。结论妇科千金胶囊联合替硝唑氯化钠注射液治疗慢性盆腔炎具有较好的临床疗效,能显著改善临床症状和血清细胞因子水平,安全性较高,具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Fuke Qianjin Capsules combined with Tinidazole and Sodium Chloride Injection in treatment of chronic pelvic inflammatory disease. Methods Patients（120 cases） with chronic pelvic inflammatory disease in Affiliated Hospital of Qinghai University from May 2015 to May 2017 were randomly divided into control group and treatment group, each group had 60 cases. Patients in the control group were iv administered with Tinidazole and Sodium Chloride Injection, 0.8 g/time, once daily. Patients in the treatment group were po administered with Fuke Qianjin Capsules on the basis of the control group, 2 grains/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and the remission time of clinical symptoms and serum cytokine levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.00% and 95.00%, respectively, and there was difference between two groups（P 〈 0.05）. Abdominal distention, pain relief time, and lumbosacral pain relief time were significantly shorter than those of control group, and the difference between the two groups was statistically significant（P 〈 0.05）. After treatment, the levels of IL-4 in two groups were significantly increased, but the levels of hs-CRP and TNF-α in two groups were significantly decreased, and the difference was statistically significant in the same group（P 〈 0.05）. After treatment, serum cytokine levels in the treatment group were significantly better than those in the control group, with significant difference between two groups（P 〈 0.05）. Conclusion Fuke Qianjin Capsules combined with Tinidazole and Sodium Chloride Injection has clinical curative effect in treatment of chronic pelvic inflammatory disease, can significantly improve the clinical symptoms and serum cytokine levels, with good safety, which has a certain clinical application value.