291名学龄期儿童幽门螺杆菌感染状况及危险因素分析

Prevalence and risk factors of Helicobactor pylori infection among 291 school-age children

目的了解学龄期儿童幽门螺杆菌(Helicobacter pylori,Hp)感染情况及其影响因素,为Hp感染的健康管理提供科学依据。方法采用Hp粪便抗原检测法对北京凤凰岭地区某小学6~13岁儿童进行Hp感染检测,同时对这些儿童的卫生习惯及生活方式等因素进行问卷调查,以分析儿童Hp感染的危险因素。结果 291名受检儿童Hp阳性率为23.02%。男童阳性率为29.19%,女童阳性率为15.38%,差异有统计学意义(P <0.05)。6~7岁、8~9岁、10~13岁儿童Hp阳性率分别为18.89%、20.62%、28.85%,Hp感染率随年龄增长呈上升趋势,但差异无统计学意义(P> 0.05)。多因素Logistic回归分析结果显示,性别、婴儿期接受口嚼喂食为Hp感染的危险因素。结论北京凤凰岭地区某小学学龄期儿童Hp感染率较高,随着年龄增长感染率呈上升趋势,男童感染率高于女童,性别、婴儿期接受口嚼喂食与感染率相关。

Objective To explore the prevalence and relevant risk factors of Helicobacter pylori（Hp） infection among school-age children. Methods Hp infections in children aged 6 to 13 years from a primary school located in Beijing Fenghuangling area were examined by monoclonal stool antigen test in this study. Standardized questionnaires were completed by parents of these children to obtain relevant information for the following analysis of risk factors. Results Hp-positive rate among 291 children was 23.02%. The positive rates in boys and girls were 29.19% and 15.38%, respectively, with a significant difference between genders（P〈0.05）. The Hp-positive rates were 18.89% in children with age of 6-7 years old, 20.62% in 8-9 years old, and 28.85% in 10-13 years old. The infection rate tended to increase with the increase of age, but the difference was not statistically significant（P〉0.05）. Multivariable regression indicated that gender and receiving pre-chewed food from mother were the high risk factors for Hp infection.Conclusion The incidence of Hp infection is a bit high among school-age children in Beijing Fenghuangling area, and the infection rate increases with the increase of age. The infection rate of boy is higher than that of girl. The rate of Hp infection has correlation with gender and receiving pre-chewed food from mother.