无针注射甘精胰岛素对2型糖尿病患者血糖及胰岛素用量的影响

Influence of insulin glargine administering by needle-free on glucose and insulin dosage in patients with type 2 diabetes mellitus

目的探讨用无针注射器注射甘精胰岛素对2型糖尿病患者血糖、胰岛素用量及血糖波动的影响。方法选取口服药联合甘精胰岛素治疗效果不佳的2型糖尿病患者50例,随机分为有针组25例和无针组25例,观察血糖变化、胰岛素用量等。结果有针组治疗前后空腹血糖、每日胰岛素用量均无明显差异(P> 0. 05);无针组治疗后空腹血糖显著下降,每日胰岛素用量明显减少(P <0. 05),与有针组相比有明显差异(P <0. 05)。结论无针注射器注射甘精胰岛素在有效降低空腹血糖的同时,每日胰岛素减量约30%,采用无针注射器注射甘精胰岛素可显著提高2型糖尿病患者的临床疗效。

Objective To investigate the influences of insulin glargine administering by needle-free on glucose and insulin dosage in patients with type 2 diabetes mellitus（T2 DM）. Methods 50 patients with T2 DM who had a poor effect of oral medicine combined with insulin glargine treatment were recruited. The patients were randomly divided into needle and needle-free group（n = 25）.The blood glucose level and insulin doses were observed. Results In the needle group,there was no significant difference in fasting blood glucose and insulin dosage before and after treatment（P 0. 05）. However,in the needle-free group,the fasting blood glucose decreased significantly,and the daily insulin dosage also decreased significantly after treatment（P 0. 05）. There was a significant difference compared with the needle group（P 0. 05）. Conclusion Insulin glargine administered by the needle-free is effective in reducing fasting blood glucose. Meanwhile,it can also reduce the daily insulin usage by 30%. Insulin glargine administered by the needle-free can significantly improve the clinical effect of T2 DM.