雷公藤多苷治疗手部侵蚀性骨关节炎临床疗效的研究

The clinical efficacy of tripterygium wilfordii polyglycoside in the treatment of erosive osteoarthritis in hands

目的研究雷公藤多苷治疗侵蚀性骨关节炎(EOA)的临床疗效。方法将17例EOA患者作为实验组,17例类风湿关节炎(RA)患者作为对照组,分别比较二者使用雷公藤多苷治疗6个月后的血沉、C-反应蛋白、VAS疼痛评分、疼痛关节数以及影像学进展等反映临床疗效的指标变化。结果结果显示,实验组使用雷公藤多苷治疗EOA患者6个月后,17例患者的血沉、C-反应蛋白、VAS疼痛评分以及疼痛关节数均有明显改善(P <0. 05)。14例(82. 4%)患者的手部X线片和手部CT无明显影像学进展,3例(17. 6%)患者的影像学检查有明显进展。对照组使用雷公藤多苷治疗RA患者6个月后,17例患者的血沉、C-反应蛋白、VAS疼痛评分以及疼痛关节数均有明显改善(P <0. 05)。10例(58. 8%)患者的手部X线片和手部CT无明显影像学进展,7例(41. 2%)患者的影像学检查有明显进展。实验组与对照组治疗后血沉、C-反应蛋白、VAS疼痛评分、疼痛关节数相比较,没有明显统计学差异(P> 0. 05)。结论使用雷公藤多苷治疗EOA与RA,疗效相当。

Objective To study the clinical efficacy of tripterygium wilfordii polyglycoside in the treatment of Erosive osteoarthritis（EOA）. Methods 17 patients with EOA were included as experimental group and 17 patients with rheumatoid arthritis（RA） as control group. The patients were treated with tripterygium wilfordii polyglycoside for 6 months. After treatment,the ESR,C-reactive protein,VAS pain scores,number of pain joints and imaging progress and other changes in the clinical efficacy of indicators were compared.Results The results showed that the number of ESR,C-reactive protein,VAS pain score and number of pain joints were significantly improved in 17 patients（P 0. 05） after 6 months of treatment with Euphorbia pulcherrima. After treatment,there were 14 cases（82. 4%） of patients with hand X-ray and hand CT without significant imaging progress,and 3 cases（17. 6%） patients with imaging progress had made significant progress. The number of ESR,C-reactive protein,VAS pain score and number of pain joints were significantly improved in 17 patients（P 0. 05） after 6 months of treatment with RA. After treatment,10 cases（58. 8%） of patients with hand X-ray and hand CT significant imaging progressed,7 cases（41. 1%） patients with imaging progress had been significant progressed. There was no significant difference in the number of ESR,C-reactive protein,VAS pain score and number of pain joints between the experimental group and the control group（P 0. 05）. Conclusion The use of tripterygium wilfordii polyglycoside in the treatment of EOA is comparable to that of RA.