摘要
Fluorescent silicon （Si） nanopartides （SiNPs） hold great promise for innumerable biological and biomedical applications owing to their unique optical properties and negligible toxicity. In this article, we present a new traditional Chinese medicine （TCM） molecule-assisted chemical synthetic strateg36 suitable for the production of multifunctional small-sized （diameter： - 3.7 nm） SiNPs in a facile and rapid （- 10 min） manner. Of particular significance, the resultant SiNPs simultaneously exhibited robust and stable fluorescence （photoluminescence quantum yield （PLQY）： ~ 15%）, as well as intrinsic anti-cancer efficacy with excellent selectivity toward cancer cells. Taking advantage of these unique merits, we further employed these novel fluorescent anti-cancer SiNPs （AC-SiNPs） for the fluorescence tracking and treatment of tumors, demonstrating long-term （~ 18 days） inhibition of tumor growth in tumor-bearing mice. Consequently, we believe this new TCM-assisted chemical synthetic method is highly attractive for designing silicon nanostructures featuring multiple functionalities, and we suggest these AC-SiNPs as novel promising tools for providing visual evidence of TCM-based cancer treatment.
Fluorescent silicon （Si） nanopartides （SiNPs） hold great promise for innumerable biological and biomedical applications owing to their unique optical properties and negligible toxicity. In this article, we present a new traditional Chinese medicine （TCM） molecule-assisted chemical synthetic strateg36 suitable for the production of multifunctional small-sized （diameter： - 3.7 nm） SiNPs in a facile and rapid （- 10 min） manner. Of particular significance, the resultant SiNPs simultaneously exhibited robust and stable fluorescence （photoluminescence quantum yield （PLQY）： ~ 15%）, as well as intrinsic anti-cancer efficacy with excellent selectivity toward cancer cells. Taking advantage of these unique merits, we further employed these novel fluorescent anti-cancer SiNPs （AC-SiNPs） for the fluorescence tracking and treatment of tumors, demonstrating long-term （~ 18 days） inhibition of tumor growth in tumor-bearing mice. Consequently, we believe this new TCM-assisted chemical synthetic method is highly attractive for designing silicon nanostructures featuring multiple functionalities, and we suggest these AC-SiNPs as novel promising tools for providing visual evidence of TCM-based cancer treatment.
基金
We thank Prof. Shuit-Tong Lee （Soochow University, China） for general help and valuable suggestions. We appreciate financial support from the National Basic Research Program of China （No. 2013CB934400）, the National Natural Science Foundation of China （Nos. 61361160412, 31400860, 21575096, and 21605109）, and a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions （PAPD）, 111 Project as well as Collaborative Innovation Center of Suzhou Nano Science and Technology （NANO-CIC）.
