摘要
内皮特异分子-1(Endocan-1),主要由活化的内皮细胞分泌,受多种细胞因子调节,通过多种信号通路参与体内多种病理生理过程。Endocan与高血压密切相关,可作为高血压患者内皮功能障碍的标志物,与相应受体结合,阻断炎症细胞进入损伤的内皮下,抑制炎症反应,发挥抗动脉粥样硬化的作用。Endocan水平可作为冠心病患者危险因素之一,且对于评估冠心病的预后有预测价值。此外Endocan还与糖尿病、慢性肾功能不全等心血管疾病常见合并症密切相关。
Endothelial sell-xpecific molecule l（endocan 1）, mainly secreted by the actived endothelial cells, was modulated by various cellular factors. Endocan 1 was involved in many pathophysiological process, such as hypertension, as a biomarker of endothelial dysfunction in hypertension patients. Endocan 1 inhibited the process of inflammation ceils entering sub-endothelium reducing inflammation, played extensive effect of anti-atherosclerosis. Endocan 1 is a risk factor of coronary heart disease and has values in evaluating the prognosis. Besides, Endocan 1 also has intimate association with cardiovascular comorbidity such as diabetes and chronic kidney disease and so on. This review is mainly discuss the molecular structure, modulation and physiological function, as well as development of Endocan in the cardiovascular disease field.
作者
周福亮
贾大林
ZHOU Fu-liang;JIA Da-lin(Department of Cardiology,the First Affiliated Hospital of China Medical University,Shenyang 110001,China)
出处
《解剖科学进展》
2018年第5期554-557,共4页
Progress of Anatomical Sciences
基金
国家自然科学基金(81670320)
