防己茯苓汤配方颗粒与传统煎剂治疗下肢深静脉血栓后遗症疗效对比

Comparison of Therapeutic Effect of Fangji Fuling Decoction Formula Granule and Conventional Fangji Fuli Decoction on Post-Thrombotic Syndrome

目的：对比观察防己茯苓汤配方颗粒与传统煎剂治疗下肢深静脉血栓后遗症（PTS）的临床疗效。方法 ：选取PTS住院患者60例,按随机数字表法分为观察组和对照组各30例。两组患者均给予常规基础治疗,观察组口服防己茯苓汤配方颗粒,对照组口服防己茯苓汤传统煎剂。比较两组患者治疗前后临床疗效、血凝五项及不良反应。结果：（1）两组患者症状、体征均较治疗前好转（P〈0.05）,组间比较差异无统计学意义（P〉 0.05）。配方颗粒组总有效率86.67%,传统煎剂组总有效率90.00%,组间比较差异无统计学意义（P〉 0.05）。（2）治疗后两组患者的凝血酶原时间（PT）、活化部分凝血酶原时间（APTT）均有延长,纤维蛋白原（FIB）有不同程度的降低,与正常人群比较差异有统计学意义（P〈0.05）,组间比较差异无统计学意义（P〉 0.05）。（3）观察组出现呕吐症状2例（6.67%）,对照组出现腹胀3例（10.00%）,组间不良反应差异无统计学意义（P〉 0.05）。结论：防己茯苓汤可以明显改善PTS患者临床症状、体征及血液学指标,且配方颗粒与传统煎剂在治疗PTS上具有等效性。

Objective：To compare and observe the clinical efficacy of Fangji Fuling decoction formula granule and conventional Fangji Fuling decoction on post-thrombotic syndrome（PTS）. Methods：Sixty hospitalized PTS patients were divided into the observation group and control group by random number table method,with 30 patients in each group. Both groups were given conventional therapy. Besides,the observation group was given oral administration of Fangji Fuling decoction formula granule,while the control group was given conventional Fangji Fuling decoction. The clinical efficacy,five indexes of blood coagulation and adverse reactions in the two groups were compared before and after treatment. Results：（1）The symptoms and signs in the two groups were better than those before treatment（P〈0.05）,and the difference between the two groups was not statistically significant（P〈0.05）. The total effective rate in the observation group was 86.67%,while that in the control group was 90.00%,and the difference between the two groups was not statistically signifi cant（P〈0.05）.（2）In both groups after treatment,prothrombin time（PT） and activated partial thromboplastin time（APTT） increased,fibrinogen（FIB） decreased with varied degree,and there was statistical difference compared with healthy people（P〈0.05）,but there was no differences between the two groups（P〈0.05）.（3）There were2 cases of vomiting in the observation group（6.67%） and 3 cases of abdominal distension in the control group（10.00%）. There was no statistically significant difference on adverse reactions between the two groups（P〉0.05）. Conclusion：Fangji Fuling decoction could significantly improve clinical symptoms,signs and hematological indexes of PTS patients,and the formula granules are equivalent to conventional decoction in the treatment of PTS.