碘/二甲基亚砜催化合成2-取代苯并咪唑

Synthesis of 2-Substituted Benzimidazole Compounds Catalyzed by I2-DMSO

探索一种合成标题化合物的新方法。以醇和邻苯二胺为原料,采用一锅法合成多功能单体标题化合物。通过单因素条件实验,确定了合成标题化合物的工艺及条件。以0.05倍物质的量的碘和5倍物质的量的二甲基亚砜为催化氧化体系,甲苯为溶剂,n（醇）∶n（邻苯二胺）=1.2∶1.0,100℃条件下,反应15 h。该方法路线简单、原料易得、标题化合物收率高,适合工业化生产。

To establish a new way of preparation of 2-substituted benzimidazole compounds,2-substituted benzimidazole compounds are prepared from alcohol and o-phenylenediamine by one-pot reaction.The conditions of the synthesis of 2-phenyl benzimidazoles are as follows： 5 mmol% iodine used as catalyst,5 mmol DMSO used as oxidant,toluene used as solvent.Material ratio of benzyl alcohol and phenyl amine is 1. 2 ∶1 under conditions of 100 ℃,15 h.The yield is high. The new route is simple,suit for a large scale and the raw materials are easily obtained.