某院体检人群血清胃蛋白酶原、胃泌素17水平与幽门螺杆菌感染的相关性研究

Correlation Study between Helicobacter pylori Infection and Serum Pepsinogen and Gastrin-17 in Physical Examination

目的探讨体检人群中幽门螺杆菌(Helicobacter Pylori,HP)的感染状况和特征,以及血清中胃蛋白酶原I(PGI)、胃蛋白酶原II(PGII)、PGR和胃泌素-17(G17)的含量与HP感染的相关性。方法应用酶联免疫吸附实验(ELISA)对宁夏医科大学总医院259例健康体检人群进行血清PGI、PGII、PGR、G17、HP的检测。使用SPSS22. 0软件,分析该人群HP感染特征;比较HP感染阳性与阴性者间血清PGI、PGII、PGR和G17水平差异及异常率。结果 259名健康体检者HP感染率为18.10%(65/259),血清PGI、PGII、PGR和G17水平均呈偏态分布,HP阳性组血清中除PGR水平低于阴性者,PGI、PGII、G17水平均明显高于阴性者(P均<0.05),且HP阳性组PGII、PGR的异常率高于HP阴性组(P均<0.05)。结论健康人群血清中PG、G17的含量与HP感染有相关性。定期测定血清PG,G17和HP抗体,可有效判断HP感染及胃功能状况,从而做到对胃肠道疾病的早期预防与治疗。

Objective To investigate the infection status and features of Helicobacter pylori（ HP） in the physical examination population and to study the correlation between Hp infection and the levels of serum pepsinogen I（ PGI）,serum pepsinogen II（ PGII） and gastrin-17（ G-17）.Methods In this study,259 cases of physical examination were included. The Serum PGI,PGII,PGR,G-17 and HP were measured by enzyme-linked immunosorbent assay.The HP infection status were analyzed by SPSS23.0 analysis system,and the difference and abnormal rate of PGI,PGII and G-17 between HP infection and non-infected groups were compared.Results The total infection rate of Hp was 18.10%,there was no significant difference in both gender and age（ P0.05）. The levels of PGI,PGII,PGR and G-17 showed a Skewed distribution.The serum concentrations of PGI,PGII and G-17 in the Hp positive group were significantly higher than those in the negative group（ P〈0.05）,while PGR showed a downward trend. The abnormal rates of PGII and PGR in the Hp positive group were significantly higher than those in the negative group（ P0.05）,while the PGI and G-17 had no significant difference（ P0.05）.Conclusion The level of serum PG and G-17 was related to HP infection.The combination of HP and serum PG and G-17 as a routine test of gastric function is of great significance in the screening and evaluation of early gastric diseases.