彩色多普勒超声对颈动脉中度狭窄患者阿托伐他汀强化治疗后颈动脉斑块厚度及体积的评价

Using improved statin treatment of unstable plaques in carotid artery moderate stenosis before and after ultrasonic image contrast research

目的:研究对比使用强化阿托伐他汀治疗不稳定斑块导致的颈动脉中度狭窄前后颈动脉斑块厚度以及体积的变化。方法:选取由不稳定斑块导致的颈动脉中度狭窄患者40例。所有患者均予以阿托伐他汀治疗,40mg/d,连续治疗3个月。对比患者治疗前后各项血脂指标水平情况,同时采用超声检查患者颈动脉斑块厚度以及斑块体积情况,并检测患者丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、肌酸激酶(CK)以及肌酐(Cr)水平。结果:治疗后患者总胆固醇与低密度脂蛋白胆固醇水平分别为(4.29±1.18)mmol/L、(2.63±1.01)mmol/L,均显著低于治疗前的(4.94±1.44)mmol/L、(3.16±1.30)mmol/L(均P<0.05)。治疗后患者颈动脉斑块厚度以及斑块体积分别为(1.20±0.31)mm、(42.55±4.51)mm3,均显著低于治疗前的(1.46±0.53)mm、(72.14±8.52)mm3(均P<0.05)。治疗前后患者AST、ALT、CK以及Cr水平对比差异无统计学意义(均P>0.05)。结论:阿托伐他汀强化治疗不稳定斑块导致的颈动脉中度狭窄效果较佳,可显著改善患者血脂水平,且安全性较好。而超声图像可有效反映患者治疗前后颈动脉斑块变化情况,可用以作为临床预后评估指标。

ObjectiveTo study the contrast using improved statin treatment of unstable plaques in carotid artery ultrasound images and analyzed before and after moderate stenosis.Methods：Chose caused by unstable plaques of carotid artery in 40 patients with moderate stenosis.All patients were given atorvastatin treatment, 40 mg/d, continuous treatment for 3 months.Contrast before and after treatment in patients with blood lipid index level, at the same time using ultrasound in patients with carotid artery plaque thickness and volume,and detect the AST, ALT, CK, and patients with Cr level.Results：After treatment in patients with total cholesterol and low density lipoprotein cholesterol respectively was （4.29±1.18） mmol/L,（2.63±1.01） mmol/L, were significantly lower than before treatment （4.94±1.44） mmol/L, （3.16±1.30） mmol/L （all P 〈0.05）.After treatment in patients with carotid artery plaque thickness and plaque volume （1.20±0.31） mm,（42.55±4.51） mm 3, were significantly lower than before treatment （1.46±1.46） mm, after （72.14±8.52） mm 3 （all P 〈0.05）.Before and after treatment in patients with AST,ALT,CK and Cr level contrast was not obvious （ P 〉0.05）.Conclusion：Atorvastatin treatment effect of unstable plaques in carotid artery moderate stenosis is better, can significantly improve patients with blood lipid levels, and better security.And ultrasound images can effectively reflect the changes before and after treatment in patients with carotid artery plaque, can be used as a clinical prognostic indicators.