胃镜下止血铗与奥美拉唑联合铝碳酸镁治疗胃十二指肠溃疡并出血的效果观察

The Effect of Endoscopic Hemostatic Spasm and Omeprazole Combined with Magnesium Aluminum Carbonate on Gastroduodenal Ulcer and Hemorrhage

目的探讨胃镜下止血铗与奥美拉唑联合铝碳酸镁治疗胃十二指肠溃疡并出血的临床疗效。方法选取我院2016年1月至2017年12月收治的胃十二指肠溃疡合并出血的患者20例,随机分为两组各10例,对照组口服奥美拉唑联合铝碳酸镁治疗,实验组在对照组的基础上同时实施胃镜下止血铗止血治疗,治疗8周后,比较两组患者的临床疗效。结果治疗8周后,两组患者的症状评分较治疗前均显著降低,且实验组症状改善情况更加优于对照组,实验组治疗有效率为100.0%,明显高于对照组的70.0%。实验组即时止血率为100.0%,无再出血发生,对照组平均止血时间(20.31±6.32)h,3例于随访期间发生再出血。两组患者均有1例发生不良反应,不良反应发生率均为10.0%,差异无统计学意义。随访6个月,实验组平均愈合时间明显短于对照组。结论胃镜下止血铗与奥美拉唑联合铝碳酸镁治疗胃十二指肠溃疡出血可实现即时止血,降低再出血率,提高溃疡愈合率,缩短愈合时间,且无明显不良反应,值得临床推广。

Objective To evaluate the clinical efficacy of endoscopic hemostasis combined with omeprazole combined with aluminum magnesium carbonate in the treatment of gastroduodenal ulcer and hemorrhage. Methods 20 patients with gastroduodenal ulcer and hemorrhage admitted from January 2016 to December 2017 in our hospital were random Ly divided into two groups. The control group received oral omeprazole combined with aluminum. In magnesium carbonate treatment,the experimental group was treated with endoscopic hemostasis and hemostasis at the same time on the basis of the control group. After 8 weeks of treatment, the clinical efficacy was compared between the two groups of patients. Results After 8 weeks of treatment, the symptom scores of both groups were significantly lower than those before treatment. The symptom improvement in the experimental group was even better than that in the control group. The effective rate in the experimental group was 100.0%, which was significantly higher than that in the control group（70.0%）. The rate of immediate hemostasis in the experimental group was 100.0%, no rebleeding occurred. The mean time to stop bleeding in the control group was（20.31±6.32） hours. During the follow-up period, rebleeding occurred. There were 1 case of adverse reactions in both groups. The incidence of adverse reactions was 10.0%, and the difference was not statistically significant. After 6 months of follow-up, the average healing time in the experimental group was significantly shorter than that in the control group. Conclusion Endoscopic hemostasis combined with omeprazole combined with aluminum magnesium carbonate in the treatment of gastroduodenal ulcer bleeding can achieve immediate hemostasis, reduce the rate of rebleeding, improve the healing rate of ulcer, shorten the healing time, and there is no obvious adverse reaction. It is worthy of clinical practice