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司来吉兰片和盐酸多奈哌齐片合用在帕金森患者中的临床效果探究 被引量:4

Clinical Efficacy of Combination of Selegilin Tablets and Donepezil Hydrochloride Tablets in Patients with Parkinson's Disease
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摘要 目的观察司来吉兰片和盐酸多奈哌齐片合用对帕金森患者的临床疗效及安全性。方法将本院自2015年6月30日至2018年6月30日收治的120例帕金森患者随机分为两组,对照组60例,口服司来吉兰片;观察组60例,口服司来吉兰片和盐酸多奈哌齐片,比较两组疗效、蒙特利尔认知评估量表(Mo CA)、简易智力状态检查量表(MMSE)、帕金森评估分量表(UPDRS)评分和药物不良反应情况。结果治疗后,观察组显效27例、好转30例、无效3例,总有效率95.00%;对照组显效20例、好转26例、无效14例,总有效率为76.66(P<0.05)。用药后,MOCA、MMSE、UPDRS评分差异均有显著性,观察组治疗效果优于对照组,差异有统计学意义(P<0.05)。用药后的不良反应包括睡眠障碍、口干和食欲不振。发生率分别为18.34%和3.34%,差异无统计学意义(P> 0.05)。结论司来吉兰联合盐酸多奈哌齐片治疗帕金森病疗效显著。提高了患者的认知能力和智能状态,不增加药物不良反应发生率。安全可靠,值得推广。 Objective To observe the clinical efficacy and safety of donepezil hydrochloride tablets combined with selegiline tablets in the treatment of Parkinson’s disease. Methods 120 patients with Parkinson’s disease were random Ly divided into control group(60 cases)and treatment group(60 cases).Control group was given selegiline and treatment group was given selegiline and hydrochloride. The curative efficacy, Montreal cognitive assessment(Mo CA), mini-mental state examination(MMSE), unified parkinson disease rating scale(UPDRS) score and adverse drug reaction were compared. Results After treatment, the effective rates in treatment group was 95.00% while in control group was 76.66%,the difference was significant(P〈 0.05).The scores of Mc CA, MMSE and UPDRS suggested the clinical effecting treatment group was better than that in the control group. The adverse drug reactions of the 2 groups were mainly sleep-disorder, dry mouth and loss of appetite and the incidence of that were 18.34% and 3.34% in treatment group and control group with no significant difference(P〉 0.05). Conclusion Donepezil hydrochloride tablets combined with selegiline tablets has significant efficacy in treating Parkinson’s disease. It works in improving patients’ cognitive ability and intelligence status without increasing the incidence of drug adverse reactions and deserves popularization.
作者 张晓韬 赵泽宇 ZHANG Xiao-tao;ZHAO Ze-yu(Weifang Medical University,Weifang,Shandong 261000)
机构地区 潍坊医学院
出处 《智慧健康》 2018年第22期76-77,80,共3页 Smart Healthcare
关键词 司来吉兰片 多奈哌齐片 帕金森病 不良反应 Parkinson’s disease Donepezil tablet Selegiline tablet Drug adverse reaction
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