高通量透析改善尿毒症血透患者心功能的临床研究

Study High flux Dialysis Improves Cardiac Function in Patients with Uremia Hemodialysis

目的研究分析高通量透析在临床中对改善尿毒症血透患者心功能的效果。方法选择于2015年3月至2018年4月到我院接受治疗的4000例尿毒症行血透的患者,遵照随机数字表法的分配法则,分为对照组(n=2000)、观察组(n=2000)。予以对照组行低通量透析治疗,予以观察组行高通量透析治疗,比较两组患者治疗后的心功能情况。结果经过不同方式治疗后,观察组SBP、DBP、P3+、i PTH、Hb、CRP、BNP、β2-MG指标水平均显著优于对照组,差异显著(P<0.05);观察组LVDd、EF、LVMI、LVPWT、E/A、IVST指标水平均显著优于对照组,差异显著(P<0.05)。结论对于尿毒症行血透的患者,行高通量透析方式治疗,能够帮助改善心功能、微炎症、贫血状态等,有效将中大分子毒素进行清除,从而促进康复,临床价值可观。

Objective To study and analyze the effect of high flux dialysis on improving cardiac function in hemodialysis patients with uremia. Methods 4000 patients with uremia who underwent hemodialysis in our hospital from March 2015 to April 2018 were selected for hemodialysis. According to the distribution rule of random number table method, it was divided into control group（n =2000） and observation group（n =2000）. The control group was treated with low-flux dialysis and the observation group was treated with high-throughput dialysis. The heart function of the two groups after treatment was compared. Results After different treatments, the SBP, DBP, P3＋, i PTH, Hb, CRP, BNP, and β2-MG levels in the observation group were significantly better than those in the control group（P〈 0.05）; LVDd, EF, and The LVMI, LVPWT, E/A, IVST indicators were significantly better than the control group, with significant differences（P〈 0.05）. Conclusion For uremic hemodialysis patients, high-throughput dialysis treatment can help improve heart function, micro-inflammation, anemia state, etc. Effectively remove toxins from macromolecules and thus promote recovery, clinical value is considerable.