分析阿奇霉素致不良反应事件的规律及特点

Analysis of the Regularity and Characteristics of Adverse Reaction Events Induced by Azithromycin

目的探讨阿奇霉素致不良反应事件的规律及特点。方法选取2017年4月至2018年4月我院采用阿奇霉素治疗引发不良事件的64例患者,回顾性分析所有患者的临床资料,并深入地探讨引发不良事件的规律及特点。结果患者消化系统、皮肤等极易出现不良反应,青年人群阿奇霉素不良反应发生情况明显高于未成年人与老年人群,首次用药不良反应发生率明显高于二次用药,静脉滴注不良反应发生率高于口服(P<0.05)。结论阿奇霉素是临床上较为常用的一种药物,但由于用药不合理继而提高了不良反应事件的发生率,临床上应加强对药物使用的管理,合理用药减少不良反应事件的发生情况,为患者的用药安全性提供保障。

Objective To investigate the regularity and characteristics of adr events induced by azithromycin. Methods Select in April 2017 to April 2018 our hospital 64 cases of patients using azithromycin treatment cause adverse events, all patients with clinical data were retrospectively analyzed, and further explore the regularity and characteristics of the cause of adverse events. Results The patients with digestive system, skin and other adverse reactions appear easily, young people azithromycin adverse reactions happen is significantly higher than the minors and the elderly, the incidence of drug adverse reactions for the first time significantly higher than the two drugs, intravenous drip the incidence of adverse reactions than oral（P〈 0.05）. Conclusion Azithromycin is the commonly used ones are a kind of clinical drug, but due to the unreasonable drug use and increased the incidence of adverse events, should strengthen the management of drug use, clinical rational drug use to reduce the occurrence of adverse events, which guarantees the safety of the patients with drug use.