高血压合并阻塞性睡眠呼吸暂停综合征患者治疗前后的血压昼夜节律变化

Circadian Rhythm of Blood Pressure before and after Treatment in Patients with Hypertension and Obstructive Sleep Apnea Syndrome

目的探讨与分析高血压合并阻塞性睡眠呼吸暂停综合征患者治疗后的效果以及血压昼夜节律变化情况。方法从本院2016年9月至2017年9月接收的高血压合并阻塞性睡眠呼吸暂停综合征患者中,随机抽取102例患者,将其进行奇偶排序,51例奇数患者作为观察组,接受常规药物联合持续气道内正压通气进行治疗,51例偶数患者作为对照组,仅接受常规药物进行治疗。观察两组临床效果。结果观察组患者治疗后总有效率高于对照组;观察组患者治疗后d DBP、d SBP、n DBP、n SBP水平均低于对照组;观察组患者治疗后AHI低于对照组,且最低Sa O_2水平、平均Sa O_2水平均高于对照组;比较结果有统计学意义(P<0.05)。结论高血压合并阻塞性睡眠呼吸暂停综合征患者昼夜血压存在较大的差异,给予患者药物联合通气治疗后能够显著改善患者的临床症状,维持血压的平衡,并改善通气情况,从而提高了患者的睡眠质量,临床价值较高,值得推广使用。

Objective To investigate and analyze the effect of blood pressure on circadian rhythm after treatment in patients with obstructive sleep apnea syndrome and hypertension. Methods From September 2016 to September 2017, 102 patients with hypertension and obstructive sleep apnea syndrome were randomly selected. They were sorted by odd and even. 51 odd-numbered patients were used as observation groups. The patients were treated with conventional drugs in combination with continuous positive airway pressure ventilation, and 51 even-numbered patients served as the control group and received only conventional drugs for treatment. Observe the clinical effects of the two groups. Results The total effective rate of the observation group after treatment is higher than that of the control group; the levels of dDBP, dSBP, nDBP, nSBP after treatment in the observation group are lower than the control group; The AHI of the observation group is lower than that of the control group after treatment the lowest SaO2 level and average SaO2 level were higher than the control group; The comparison results were statistically significant （P〈0.05）. Conclusion There is a significant difference in day-night blood pressure in patients with hypertension and obstructive sleep apnea syndrome. The combination of medication and ventilation given to patients can significantly improve the patient＇s clinical symptoms, maintain blood pressure balance, and improve ventilation, thereby improving the sleep treatment of patients is of high clinical value and worthy of promotion.