评价C反应蛋白测定在非溶血性输血不良反应中的诊断价值

Evaluation of C-reactive Protein in the Diagnosis of Non-hemolytic Transfusion Reactions

目的研究分析C反应蛋白测定在非溶血性输血不良反应中的临床诊断价值。方法选取2014年4月至2018年4月在我院接受输血并发生不良反应的病患95例,其中有45例病患发生非溶血性发热不良反应将其设为发热组,有50例病患发生非溶血性过敏不良反应将其设为过敏组,另外抽选45例未出现输血不良反应病患设为对照组,所有病患采取5m L的静脉血,并使用免疫荧光法测定病患输血前后的全血C反应蛋白水平,进行对比分析。结果对比过敏组和发热组输血前后的全血C反应蛋白水平,差异具有统计学意义(P<0.05),比较过敏组及发热组与对照组输血后的全血C反应蛋白水平,差异具有统计学意义(P<0.05)。结论 C反应蛋白是一种炎症指标,发生非溶血性输血不良反应的时候,C反应蛋白明显增高,对于非溶血性输血不良反应的诊断中,C反应蛋白测定有着一定的临床诊断价值。

Objective To analyze the clinical diagnostic value of C-reactive protein in non-hemolytic transfusion reactions.Methods 95 patients who received blood transfusion and had adverse reactions in our hospital from April 2014 to April 2018 were selected.Among them,45 patients developed non-hemolytic febrile reactions and set them as a fever group.There were 50 cases of adverse reactions of non hemolytic hypersensitivity and set them as a anaphylaxis group.45 patients had no adverse reactions were set as a control group.All patients took 5 m L of venous blood and measured the level of whole blood C-reactive protein before and after transfusion using immunofluorescence.Results The levels of whole blood C-reactive protein before and after transfusion in allergic and fever groups were statistically significant（P0.05）.The levels of C-reactive protein in after blood transfusion were compared between the allergic group and the fever group and the control group,the difference was statistically significant（P0.05）.Conclusion C-reactive protein is an inflammatory marker.C-reactive protein is significantly increased when non-hemolytic transfusion reactions occur.For the diagnosis of non-hemolytic transfusion reactions,C-reactive protein assay has a certain clinical diagnostic value.