卡托普利治疗小儿急性肾炎高血压的疗效评价

Efficacy evaluation of Captopril in the treatment of pediatric acute nephritis complicated with hypertension

目的探讨卡托普利治疗小儿急性肾炎高血压的疗效。方法 90例小儿急性肾炎高血压患儿,随机分为对照组和观察组,各45例。对照组予以常规用药治疗,观察组在对照组基础上联合卡托普利治疗。比较两组转归率;血压降低到正常范围的时间、水肿减轻时间、尿少症状消失时间、血尿消失时间;治疗前后患儿肾功能指标、舒张压、收缩压;不良反应发生情况。结果观察组患儿转归率为97.78%,明显高于对照组的71.11%,差异具有统计学意义(P<0.05)。治疗前,两组24 h尿蛋白、血肌酐、尿素氮、舒张压、收缩压比较,差异无统计学意义(P>0.05);治疗后,观察组24 h尿蛋白、血肌酐、尿素氮、舒张压、收缩压优于对照组,差异具有统计学意义(P<0.05)。观察组患儿血压降低到正常范围的时间、水肿减轻时间、尿少症状消失时间、血尿消失时间均短于对照组,差异具有统计学意义(P<0.05)。两组患儿不良反应发生率比较,差异无统计学意义(P>0.05)。结论常规用药联合卡托普利治疗小儿急性肾炎高血压的疗效确切,可有效改善肾功能指标、舒张压、收缩压,快速改善临床症状,无严重不良反应,值得推广应用。

Objective To investigate the efficacy of Captopril in the treatment of pediatric acute nephritis complicated with hypertension. Methods A total of 90 acute nephritis children complicated with hypertension were randomly divided into control group and observation group, 45 cases in each group. The control group was given conventional medication, the observation group was treated with Captopril on the basis of the control group. The conversion rate, the time of blood pressure drop to normal range, edema reduction time, the disappearance of oliguria symptoms and hematuria, the renal function, diastolic blood pressure and systolic blood pressure before and after treatment, the occurrence of adverse reactions between the two groups were compared. Results The conversion rate of children in the observation group was 97.78%, which was significantly higher than 71.11% in the control group, the difference was statistically significant（P〈0.05）. Before treatment, there were no significant differences in the 24 hours urinary protein, serum creatinine, urea nitrogen, diastolic blood pressure and systolic blood pressure between the two groups（P〉0.05）. After treatment, the 24 hours urinary protein, serum creatinine, urea nitrogen, diastolic blood pressure and systolic blood pressure of the observation group were significantly better than those of the control group, the differences were statistically significant（P〈0.05）. The time of blood pressure drop to normal range, edema reduction time, the disappearance of oliguria symptoms and hematuria in the observation group were significantly shorter than those in the control group, the differences were statistically significant（P〈0.05）. There was no significant difference in the incidence of adverse reactions between the two groups（P〉0.05）. Conclusion The conventional medication combined with Captopril in the treatment of pediatric acute nephritis complicated with hypertension has obvious curative effect, can effectively improve renal function indexes, diastolic blood pressure, systolic blood pressure, rapidly improve the clinical symptoms, and with no serious adverse reactions. It is worthy of popularization and application.