地佐辛在创伤早期镇痛的临床研究

Clinical study of Dezocine in the analgesia for early stage of trauma

目的探究地佐辛、曲马多在创伤早期镇痛中的应用效果及安全性。方法 200例创伤早期患者作为研究对象,随机分为实验组与对照组,各100例。两组患者均采用单盲给药。实验组给予地佐辛10 mg肌内注射,对照组给予曲马多100 mg肌内注射,观察比较两组患者治疗后15、30、60、120 min的视觉模拟评分法(VAS)评分、舒适度(BCS)评分、镇静(Ramsay)评分及不良反应发生情况。结果实验组治疗后15、30、60、120 min的VAS评分分别为(2.43±1.58)、(2.12±0.58)、(1.93±0.67)、(2.20±0.96)分,均明显低于对照组的(2.91±1.82)、(2.70±0.82)、(2.57±0.71)、(2.92±0.75)分,差异具有统计学意义(P<0.05);实验组治疗后15、30、60、120 min的BCS评分分别为(1.89±0.76)、(2.87±0.95)、(2.78±0.89)、(2.98±0.81)分,均明显高于对照组的(1.01±0.95)、(2.28±0.79)、(1.98±0.87)、(2.64±0.73)分,差异具有统计学意义(P<0.05);实验组治疗后15、30、60、120 min的Ramsay评分分别为(2.51±0.83)、(2.32±0.52)、(2.27±0.63)、(1.99±0.50)分,均明显高于对照组的(1.98±0.81)、(1.97±0.58)、(1.81±0.33)、(1.86±0.39)分,差异具有统计学意义(P<0.05);实验组不良反应发生率为7.00%,明显低于对照组的16.00%,差异具有统计学意义(P<0.05)。结论地佐辛早期镇痛效果显著,起效快、作用强、不良反应少,是一种理想的创伤早期镇痛药,值得临床推广应用。

Objective To investigate the application effect and safety of Dezocine and Tramadol in the analgesia for early stage of trauma. Methods A total of 200 patients with early stage of trauma were selected as research objects, they were randomly divided into experimental group and control group, 100 cases in each group. Patients of the two groups were given single blind administration. The experimental group was given intramuscular injection of Dezocine 10 mg, the control group was given intramuscular injection of Tramadol 100 mg. The scores of visual analog scale（VAS）, Bruggrmann comfort scale（BCS）, Ramsay sedation scale after 15, 30, 60, 120 min of treatmnet and the occurrence of adverse reactions between the two groups were compared. Results The VAS scores of the experimental group after 15, 30, 60, 120 min of treatment were（2.43±1.58） scores,（2.12± 0.58） scores,（1.93±0.67） scores and（2.20±0.96） scores respectively, which were significantly lower than（2.91±1.82） scores,（2.70±0.82） scores,（2.57±0.71） scores and（2.92±0.75） scores of the control group, the differences were statistically significant（P〈0.05）. The BCS scores of the experimental group after 15, 30, 60, 120 min of treatment were（1.89±0.76） scores,（2.87±0.95） scores,（2.78±0.89） scores and（2.98±0.81） scores respectively, which were significantly higher than（1.01±0.95） scores,（2.28±0.79） scores,（1.98±0.87） scores and（2.64±0.73） scores of the control group, the differences were statistically significant（P〈0.05）. The scores of Ramsay sedation scale in the experimental group after 15, 30, 60, 120 min of treatment were（2.51±0.83） scores,（2.32±0.52） scores,（2.27±0.63） scores and（1.99±0.50） scores respectively, which were significantly higher than（1.98±0.81） scores,（1.97±0.58） scores,（1.81±0.33） scores and（1.86±0.39） scores in the control group, the differences were statistically significant（P〈0.05）. The incidence of adverse reactions in the experimental group was 7.00%, which was significantly lower than 16.00% in the control group, the difference was statistically significant（P〈0.05）. Conclusion The analgesia effect of Dezocine for early stage of trauma is significant, with quick onset, strong effect and less adverse reactions. It is an ideal analgesic for early stage of trauma and worthy of clinical promotion and application.