门冬氨酸鸟氨酸联合乳果糖治疗肝硬化肝性脑病效果分析

Effect analysis of Ornithine Aspartate combined with Lactulose on liver cirrhosis complicated with hepatic encephalopathy

目的探讨门冬氨酸鸟氨酸联合乳果糖治疗肝硬化肝性脑病的临床效果。方法 60例肝硬化肝性脑病患者,随机分为观察组和对照组,各30例。在常规治疗基础上,对照组给予门冬氨酸鸟氨酸治疗,观察组同时应用门冬氨酸鸟氨酸联合乳果糖治疗。观察两组患者神志转为清醒时间、治疗3 d后尿量情况、自发性腹膜炎和肝肾综合征发生情况,并检测两组患者治疗前后血氨水平。结果观察组神志转为清醒时间<1 d患者占50.0%,明显高于对照组的3.3%;观察组治疗3 d后尿量>1000 ml占70.0%,明显高于对照组的20.0%,差异具有统计学意义(P<0.05)。观察组自发性腹膜炎和肝肾综合征发生率分别为10.0%、6.7%,均明显低于对照组的33.3%、26.7%,差异具有统计学意义(P<0.05)。治疗前,两组血氨水平比较差异无统计学意义(P>0.05);治疗后,两组血氨水平均明显降低,且观察组血氨水平明显低于对照组,差异具有统计学意义(P<0.05)。结论门冬氨酸鸟氨酸联合乳果糖治疗肝硬化肝性脑病临床效果显著,值得借鉴。

Objective To investigate the clinical effect of Ornithine Aspartate combined with Lactulose in the treatment of liver cirrhosis complicated with hepatic encephalopathy. Methods A total of 60 liver cirrhosis patients complicated with hepatic encephalopathy were randomly divided into the observation group and the control group, 30 cases in each group. In addition to conventional therapy, the control group was given Ornithine Aspartate for treatment, and the observation group was given Ornithine Aspartate combined with Lactulose for treatment. The time of consciousness turns to sober, the urine volume after 3 days of treatment, occurrence of spontaneous peritonitis and hepatorenal syndrome between the two groups were observed, the blood ammonia levels were detected before and after treatment in two groups. Results The proportion of consciousness turns to sober time less than one day in the observation group was 50.0%, which was significantly higher than 3.3% in the control group, the proportion of urine volume more than 1000 ml after 3 days of treatment in the observation group was 70.0%, which was significantly higher than 20.0% in the control group, the differences were statistically significant（P〈0.05）. The incidence of spontaneous peritonitis and hepatorenal syndrome in the observation group were 10.0% and 6.7% respectively, which were significantly lower than 33.3% and 26.7% in the control group, the differences were statistically significant（P〈0.05）. Before treatment, there was no significant difference in the blood ammonia level between the two groups（P〉0.05）. After treatment, the levels of blood ammonia in the two groups were significantly lower than those before treatment, and the blood ammonia level in the observation group was significantly lower than that in the control group, the differences were statistically significant（P〈0.05）. Conclusion The clinical effect of Ornithine Aspartate combined with Lactulose in the treatment of liver cirrhosis complicated with hepatic encephalopathy is significant, is worthy of reference.