摘要
目的:观察服用维生素D(VD)联合ω-3脂肪酸治疗孤独症(autism spectrum disorder,ASD)患儿的疗效。方法:本研究为48名年龄在5~12岁、新诊断的ASD患儿参与的随机双盲临床试验。患儿分成4组,每组12例。对照组患儿服用安慰剂,VD组患儿服用VD 800U/d,ω-3脂肪酸组患儿服用ω-3脂肪酸900mg/d,联合用药组患儿联合服用VD 800U/d及ω-3脂肪酸900mg/d。用药同时所有患儿针对症状进行结构化训练,地点为医院,时间为4h/d,每周5d。在用药12个月后采用儿童孤独症评定量表(Childhood Autism Rating Scale,CARS)评估治疗后的临床症状改善情况。结果:治疗12个月后,与对照组比较,VD组及联合用药组患儿大部分CARS评分明显降低(P<0.05)。联合用药组患儿视觉反应及听觉反应评分较VD组下降更明显(P<0.05),且联合用药组焦虑反应评分较ω-3脂肪酸组下降更明显(P<0.05)。结论:在结构化训练的同时补充VD或VD联合ω-3脂肪酸可有效改善ASD患儿的症状。VD联合ω-3脂肪酸有望成为治疗儿童ASD的有效辅助方法。
Objective: To observe the efficacy of vitamin D combined with ω-3 fatty acid in treatment of children with au tism spectrum disorder (ASD). Methods: Forty eight children aged 5 to 12 years old who were newly diagnosed as ASD were enrolled for the randomized double blind clinical trial .All the patients were randomly divided into 4 groups ,each consisting of 12 patients .The patients in the control group received placebo , while the patients in the vitamin D group received vitamin D at a dosage of 800 U/d, and the patients in the ω-3 fatty acid group received ω-3 fatty acid at a dosage of 900 mg/d .The patients in the combined treatment group received vitamin D (800 U/d) and ω-3 fatty acid (900 mg/d).During treatment ,all the patients were trained by using Treatment and Education of Autistic and related Communication handicapped Children (TEACCH) inter vention approach in the hospital ,4 hours a day ,5 days a week .Clinical symptoms were evaluated by Childhood Autism Rating Scale(CARS) 12 months after treatment .Results: After 12 months of treatment ,the scores of CARS significantly decreased in the vitamin D group and the combined treatment group compared with those of the control group (P〈0.05).Compared to the vitamin D group ,the scores of visual and auditory response in the combined treatment group dropped more significantly (P〈0.05 ). Compared to the ω-3 fatty acid group ,the scores of anxiety of the combined treatment group decreased more significantly (P〈0.05 ).Conclusion: Vitamin D or vitamin D combined with ω-3 fatty acid supplemented with TEACCH intervention approach could improve symptoms of children with ASD .Vitamin D plus ω-3 fatty acid could be an effective adjuvant treatment for children with ASD .
作者
方乐
蒋雪明
黄彦科
孙彦香
谢雨芳
王鹭
FANG Le;JIANG XueMing;HUANG YanKe;SUN YanXiang;XIE YuFang;WANG Lu(Department of Children Rehabilita tion,Maternal and Child Health Care Hospital of Nanshan District,Shenzhen,Shenzhen Guangdong 518000,China)
出处
《药学服务与研究》
CAS
2018年第5期347-350,共4页
Pharmaceutical Care and Research
基金
深圳市南山区技术研发和创意设计项目(南科研卫2017051号)
关键词
孤独症
儿童
维生素D
Ω-3脂肪酸
autism spectrum disorder
child
vitamin D
ω-3 fatty acid