多巴丝肼片联合视力遮盖法治疗儿童弱视的临床疗效

Clinical effect of levodopa and benserazide hydrochloride tables combined with visual occlusion for amblyopia in children

目的:研究视力遮盖法联合口服多巴丝肼片对弱视儿童患者的治疗效果。方法:选取2016-01/2017-01在我院确诊患有弱视的儿童90例140眼,随机分成单一治疗组和联合治疗组,并选取35例70眼健康儿童作为正常组进行比较。单一治疗组患者采用视力遮盖法进行治疗,联合治疗组患者在使用视力遮盖法的基础上口服多巴丝肼片进行联合治疗。提取两组患儿治疗前后和正常组的泪液,采用酶联免疫吸附法对140眼弱视患儿及正常组儿童70眼泪液中IL-1β、IL-6和IL-9进行检测,采用免疫透射比浊法检测140眼弱视患儿及正常组儿童70眼泪液中环磷腺苷效应元件结合蛋白(CREB)、PKA的蛋白水平。比较两组患者及正常组的指标水平以及不同年龄组治疗有效率及不同方法治疗总有效率。结果:治疗后,联合治疗组泪液中IL-1β、IL-6、IL-9和CREB、PKA水平明显低于单一治疗组,差异有统计学意义(P<0. 05);联合治疗组和单一治疗组患儿3～6岁阶段的治疗总有效率显著高于7～9岁和10～12岁阶段的治疗总有效率,差异有统计学意义(P<0. 05);联合治疗组治疗总有效率明显高于单一治疗组,差异有统计学意义(P<0. 05)。结论:多巴丝肼片联合视力遮盖法能够对儿童的弱视情况作出及时的改善治疗,治疗时间阶段越早越好,且有效率较高。

AIM：To study the therapeutic effect of visual occlusioncombined with levodopa and benserazide hydrochloridetables on children with amblyopia.METHODS： Totally 90 cases （ 140 eyes ） of childrendiagnosed with amblyopia in our hospital were selectedfrom January 2016 to January 2017. They were randomlydivided into the monotherapy group and the combinedtreatment group, and 35 healthy children （70 eyes） wereselected as the normal group for comparison. Patients inthe monotherapy group were treated with visual cover,while patients in the combined treatment group weretreated with oral administration of levodopa andbenserazide tablets on the basis of visual cover. Tearswere extracted from both groups of children before andafter treatment, and the protein levels of CREB and PKAin tears of 140 eyes and 70 eyes of children in the normalgroup were detected by enzyme- linked immunosorbentassay. The index levels of the two groups and thenormal group were compared, as well as the therapeuticefficiency of different age groups and the totaltherapeutic efficiency of different methods.RESULTS： After treatment, the levels of IL - 1β, IL - 6 and IL - 9 in the combined treatment group weresignificantly lower than those in the single treatmentgroup after treatment （ P 〈 0. 05 ）. After treatment, thelevels of CREB and PKA in the combined treatment groupwere significantly lower than those in the singletreatment group （ P 〈 0. 05 ）. The total effective rate ofchildren at the age of 3 - 6 in the combined treatmentgroup and the single treatment group was significantlyhigher than those at the age of 7 - 9 and 10 - 12 in eachgroup （P〈 0郾 05）. The total therapeutic efficiency of thecombined treatment group was significantly higher thanthat of the single treatment group, and the differencewas statistically significant （P〈0. 05）.CONCLUSION： Combined with the traditional maskingmethod, levodopa and benserazide hydrochloride tablescan improve the treatment of children＇s amblyopia. Theearlier the treatment time, the better and the higherefficiency is.