我院美罗培南合理用药分析

Analysis of rational usage of meropenem in our hospital

目的:分析我院美罗培南的临床用药情况,促进美罗培南的临床合理用药。方法:回顾性分析2016年1月至2017年12月我院住院使用美罗培南的97份病历资料,并对药物使用情况、临床疗效、不良反应和用药合理性进行分析。结果:97例患者中,使用美罗培南位居前3位的科室分别为外科重症监护室(23例,23.71%)、内科重症监护室(14例,14.43%)、呼吸内科(11例,11.34%),其中有76例进行了细菌培养,送检率为78.35%,美罗培南的用药频率(DDDs)为756.8,药品利用指数(DUI)为1.16,不良反应发生率为15.46%,临床治疗总有效率为85.57%,合理用药率为87.63%,不合理用药率为12.37%,其中无指征用药在所有不合理用药情况中所占比例最高。结论:我院对美罗培南的临床应用基本合理,但也存在不合理用药情况,在美罗培南的临床使用中应严格按照规定使用,减少经验用药,提高送检率,以提高临床疗效及合理用药水平。

AIM： To analyze the situation of clinical usage of meropenem in our hospital and to promote the rational usage of meropenem. METHODS： Ninety-seven medical records of meropenem hospitalized in our hospital from January 2016 to December 2017 were retrospectively analyzed for the drug usage,clinical efficacy,adverse reactions,and rationality of medication. RESULTS： Of the 97 patients,the top 3 departments using meropenem were surgical intensive care unit（23 cases,23. 71%）,internal medicine intensive care unit（14 cases,14. 43%）, and respiratory medicine department（11 cases,11. 34%）. Seventy-six cases were cultured with bacteria, the submission rate was78. 35%,the defined daily doses（DDDs） of meropenem were 756. 8, the drug utilization index（DUI） was 1. 16,the adverse reaction rate was15. 46%,the total effective rate of clinical treatment was 85. 57%,and the rational drug usage rate was87. 63%. The irrational drug usage rate was12. 37%,of which the non-indicative drug usage accounted for the highest proportion in all unreasonable drug usage cases. CONCLUSION： The clinical application of meropenem in our hospital is basically reasonable,but there are also cases of irrational usage. Clinical prescribes of meropenem should strictly follow the regulations to reduce experience-directed drug usage,improve the submission rate in order to enhance the efficacy of rational drug usage.