氧化苦参碱抗炎及其作用机制的研究进展

Research Advances on Anti-inflammation Effects and Mechanism of Oxymatrine

氧化苦参碱对各种急慢性炎症(包括免疫性和非免疫性炎症)均有抗炎作用。氧化苦参碱可能是通过上调微小RNA-211-5p表达,下调把关受体-4/髓样分化因子-88/核因子-κB信号通路,抑制吞噬细胞、淋巴细胞和受损组织细胞的炎性细胞因子(如IL、肿瘤坏死因子、抗体等)的表达和上调抗炎细胞因子IL-10的表达,产生抗炎作用。氧化苦参碱还可通过抑制环氧化酶、炎症介质前列腺素生物合成以及花生四烯酸转化成白三烯,也可通过稳定细胞膜抑制肥大细胞释放组织胺,产生抗炎作用。综述氧化苦参碱抗炎及其作用机制的文献资料,并对其研究进展做了分析。

Oxymatrine has anti-inflammatory effects against various acute and chronic inflammation（including immune and non-immune inflammation）. Oxymatrine anti-inflammatory effects are produced by up-regulating the expression of miRNA-211-5 p to inhibit TLR4/MyD88/NF-κB signaling pathway by and down-regulating the expression of inflammatory cytokines（such as interleukins, tumor necrosis factor-α, and antibody）; by and up-regulating the expression of anti-inflammatory cytokine interleukin-10 of phagocyte, lymphocyte and injuring tissular cells,and by inhibiting cycloxygenase to decrease prostaglandin biosynthesis, by inhibiting arachidonic acid transformation to leukotriene,and by stabilizing cell membrane to inhibit histamine release from mastocyte. The literatures on the anti-inflammatory effects and mechanism of oxymatrine were reviewed and the research progress was analyzed.