免疫球蛋白联合C3补体检测对原发性肾病综合征的诊断价值评价

Diagnostic Value of Immunoglobulin Combined with C3 Complement Detection in Primary Nephrotic Syndrome

目的探索免疫球蛋白联合C3补体检测对原发性肾病综合征的诊断价值。方法在2017年2月23日至2018年2月23日期间选取对照组100例健康体检者、观察组115例疑似原发性肾病综合征患者为此次实验对象,且均进行C3补体、免疫球蛋白等指标检测。结果观察组受检者的Ig A(2.64±0.55)g/L、Ig E(238.94±15.36)ug/m L、Ig M(2.48±0.12)g/L高于对照组(P<0.05),Ig G(5.22±1.35)g/L、C3(1.02±0.06)g/L低于对照组(P<0.05),同时免疫球蛋白联合C3补体诊断对原发性肾病综合征患者的敏感性、特异性、误诊率、漏诊率分别为98.00%、93.33%、6.67%、2.00%。结论加强原发性肾病综合征患者的免疫球蛋白联合C3补体检测,能够预测肝肾功能,为后期治疗提供科学依据。

Objective To explore the diagnostic value of immunoglobulin combined with C3 complement in the diagnosis of primary nephrotic syndrome. Methods In the period from February 23, 2017 to February 23, 2018, 100 healthy subjects in the control group and 115 patients with suspected primary nephrotic syndrome in the observation group were selected as the subjects of this study,immunoglobulin and other indicators detected. Results Ig A（2.64±0.55） g/L, Ig E（238.94±15.36） ug/m L, Ig M（2.48±0.12） g/L in the observation group were higher than those in the control group（P〈0.05）, and Ig G（5.22±1.35）g/L, C3（1.02±0.06）g/L were lower than those in the control group（P〈0.05）, at the same time, the sensitivity, specificity, misdiagnosis rate and missed diagnosis rate of immunoglobulin combined with C3 complement were 98.00%, 93.33%, 6.67% and 2.00% respectively. Conclusion The detection of immunoglobulin combined with C3 complement in patients with primary nephrotic syndrome can predict liver and kidney function and provide scientific basis for later treatment.