肺咳停颗粒止咳、祛痰、平喘、抗炎作用研究

Pharmaco dynamic studying of Feiketing Granules

目的研究肺咳停颗粒的止咳、祛痰、平喘、抗炎作用。方法通过浓氨水诱发小鼠咳嗽模型,观察肺咳停颗粒(0.97、1.94、3.88 g生药/kg)止咳作用;通过小鼠酚红分泌实验,观察其祛痰作用;通过卵蛋白诱发豚鼠哮喘模型,观察其(0.59、1.18、2.36 g生药/kg)平喘作用;通过大鼠琼脂肉芽肿炎症模型,观察其(0.67、1.34、2.68 g生药/kg)抗炎作用;通过小鼠二甲苯耳肿胀炎症模型,观察其抗炎作用。结果与对照组比较,肺咳停颗粒低、中、高剂量组均能延长小鼠咳嗽潜伏期、减少2 min内咳嗽次数;增加小鼠酚红分泌量;延长豚鼠哮喘发作潜伏期;抑制大鼠琼脂块的生长和小鼠耳肿胀程度,并且呈现一定量效关系(P<0.05、0.01)。结论肺咳停颗粒具有一定的止咳、祛痰、平喘、抗炎作用。

Objective To investigate the Feiketing Granules on the relieving cough, eliminating sputum, relieving asthma, and anti-inflammatory. Methods The effects by the model of mouse induced by strong ammonia, the amount of phenol red seretion by mouse, guinea pig asthmaed by egg albumin, the agar granuloma model of rat and the ear swelling model of mouse induced by xylene soiution was studied. Results Compared with the blank control group, the low-, medium-, and high-dosage group of Feiketing Granules could prolong the cough incubation period of mouse, reduce the number of cough in two minutes, increase the secretion of phenol red, increase asthma incubation period of guinea pig, decrease the weight of the agar granuloma and ear swelling, meanwhile existing the dose-effect relationship（P 0.05 and 0.01）. Conclusions The results showed Feiketing Granules could relieve cough, eliminat sputum, relieve asthma, and have anti-inflammatory effect.