雷公藤多苷联合塞来昔布治疗类风湿关节炎的临床效果研究

Clinical study of Tripterysium Glycosides combined with celecoxib in treatment of rheumatoid arthritis

目的研究雷公藤多苷联合塞来昔布治疗类风湿关节炎的临床效果。方法选择2014年1月—2015年12月在西安市第五医院进行诊治的类风湿关节炎患者60例,随机分为两组,每组各30例。对照组口服塞来昔布治疗,每次200 mg,每天2次;观察组联合口服雷公藤多苷片治疗,每次20 mg,每天3次。两组均治疗3个月。比较两组的临床治疗效果,观察治疗前后的血清C反应蛋白、类风湿因子和红细胞沉降率,血清白介素-6、肿瘤坏死因子-α以及白介素-23水平。结果观察组的有效率为93.33%(28/30),明显高于对照组的73.33%(22/30),差异有统计学意义(P<0.05)。治疗后两组的血清C反应蛋白、类风湿因子和红细胞沉降率均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且观察组明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组的白介素-6、肿瘤坏死因子-α以及白介素-23均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且观察组明显低于对照组,差异有统计学意义(P<0.05)。两组的不良反应率相比无明显差异。结论雷公藤多苷联合塞来昔布治疗类风湿关节炎的临床效果明显优于单纯使用西药塞来昔布治疗,是一种安全有效的治疗方法。

Objective To investigate the clinical effect of Tripterysium Glycosides combined with celecoxib in the treatment of rheumatoid arthritis. Methods Selected 60 cases of patients with SAP who were treated in our hospital from January 2014 to December 2015, divided into two groups randomly. The control group was treated with celecoxib, each time 200 mg, 2 times a day; the observation group was treated with oral Tripterysium Glycosides, 20 mg per day, 3 times a day. The clinical effects of the two groups were compared. The serum C reactive protein, rheumatoid factor and erythrocyte sedimentation rate, serum interleukin-6, tumor necrosis factor alpha and interleukin-23 levels were observed before and after treatment. Results After treatment, the effective rate of the observation group was 93.33%（28/30）, significantly higher than that of the control group 73.33%（22/30）（P〈0.05）. After treatment, the serum C reactive protein, rheumatoid factor and erythrocyte sedimentation rate of the two groups were significantly lower（P〈0.05）, and the observation group was more obvious（P〈0.05）. The levels of interleukin-6, tumor necrosis factor alpha and interleukin-23 in the two groups were significantly lower（P〈0.05）, and the observation group was more obvious（P〈0.05）. There was no significant difference in the adverse reaction rate between the two groups. Conclusion The clinical effect of Tripterysium Glycosides combined with celecoxib in the treatment of rheumatoid arthritis is better than that of western medicine celecoxib alone.