肠道菌群与非酒精性脂肪性肝病的关系

The relationship between gut microbiota and non-alcoholic fatty liver disease

非酒精性脂肪性肝病（NAFLD）是与遗传、环境相关的代谢应激性肝损伤，被认为是代谢综合征在肝脏的表现。肠道菌群是肠道内环境的重要组成部分。近年来越来越多的研究结果提示肠道菌群失衡与NAFLD密切相关。现对肠道菌群在NAFLD发病及疾病进展中的作用机制和NAFLD以肠道菌群为靶点的新的治疗手段进行综述。

Nonalcoholic fatty liver disease（NAFLD）, which is a kind of irritable liver injury related to genetic and environmental factors, is considered as the manifestation of metabolic syndrome in the liver. Gut microbiota plays an important role in the intestinal environment. In recent years, increased numbers of studies have suggested that the imbalance of intestinal flora is closely related to NAFLD. This paper is to review the mechanism of gut microbiota in the pathogenesis and progression of NAFLD and to comment on gut microbiota-targeting new treatment of NAFLD by regulating the intestinal flora.