系统性红斑狼疮合并肝损害危险因素的Meta分析

Meta analysis of the risk factors that set the SLE patients up for lupus hepatitis

目的探讨系统性红斑狼疮(SLE)患者发生狼疮性肝损害(lupus hepatitis,LH)的可能危险因素。方法在4个数据库(PubMed、medline、万方、中国知网)中发表的文章进行搜索,检索文献发表时间均为从建库至2017年9月以确定具有LH的SLE患者的文章。提取临床和实验室数据,并进行荟萃分析以确定患有SLE肝损害的危险因素。4个数据库共发现文献232篇,最终纳入文献11篇。结果分析结果显示:抗C3抗体、高SLEDAI评分、血清IgG水平升高及神经系统受累因素差异有统计学意义(P<0.05)。结论血清抗C3抗体水平下降、IgG球蛋白水平升高、SLEDAI评分较高及神经系统受累可能是系统性红斑狼疮患者发生肝损害的危险因素。

Objective The purpose of this research was to discuss the risk factors that set the SLE patients up for lupus hepatitis.Methods The articles published from the setup of the database to September 2017 among 4 databases（PubMed,Medline,Wan Fang,CNKI）in order to find out articles related with SLE patients suffering from LH were searched.Extract both clinical data and laboratory data,afterwards using meta-analysis were used to determine the risk factors that set the SLE patients up for LH.Altogether 232 articles had been found within 4 databases and among which 11 have been selected into account.Results The result of the combined analysisshown that anti-C3 antibody,SLEDAI Scores,IgG,nervous system involvement,the above differences hae statistical significance（P〈0.05）.Conclusion Current evidence suggests that the decline of Serum anti-C3 antibody levels,the rise of IgG levels,the higher scores of SLEDAI and nervous system involvement might be the risk factors that set the SLE patients up for lupus hepatitis.