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miRNA-7在鼻咽癌中的表达及临床意义 被引量:2

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摘要 鼻咽癌为临床常见恶性肿瘤,在我国南方发病率较高。研究证实鼻咽癌的发病不仅与EB病毒及致癌物质有关,还与细胞中某些癌基因的激活、抑癌基因的失活有关^([1])。微小RNA(microRNA,miRNA)为一类小RNA分子,在基因的表达调控过程中发挥重要作用,目前是世界范围内生命科学领域研究的热点。虽然已有研究证实miRNA的异常表达与鼻咽癌的发生发展密切相关^([2]),但关于鼻咽癌组织中miRNA的确切调控机制还有待进一步研究。
出处 《中国耳鼻咽喉头颈外科》 CSCD 2018年第9期478-480,共3页 Chinese Archives of Otolaryngology-Head and Neck Surgery
关键词 鼻咽肿瘤 微RNAS Nasopharyngeal Neoplasms MicroRNAs
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  • 1Wu Z, Weng D, I,i G, Quantitative proteome analysis of overex-pressed Cripto - 1 tumor cell rew'als 14 - 3 - 3gamma as a novel biomarker in nasopharyngeal carcinoma [ J ]. J Proteomies, 2013, 83:26 - 36.
  • 2Arnoht M,Wildeman MA,Visser O,et al. Lower mortality from na-sopharyngeal cancer in The Netherlands since 1970 with differential ineidenee trends in histopathology [ J ]. Oral Oneolngy, 2013,49 : 237 - 243.
  • 3Jin B, Dong P, Li K, el al. Meta - analysis of the association between GSTT1 null genotype and risk of nasopharyngeal carcinoma in Chinese[ J ]. Tumnur Bio1,2014,35 : 345 - 349.
  • 4Sun GG, Lu YF, Fu ZZ,el al. EMP1 inhibits nasopharyngeal cancer cell growth and metastasis through induction apoptosis anti anglo- genesis [ J ]. Turnout Biol, 2014,35:3185 - 3193.
  • 5Ben Chaahen A, Busson M, Douik H, et al. Association of IL - 12p40 +1188 A/C polymorphism with nasopharyngeal cancer risk and tumor extension[ J]. Tissue Antigens,2011,78 : 148 - 151.
  • 6Li M ,Dai W,Zhou 1t. Cyelin D1 G870A polymorphism and risk of nasopharyngeal carcinoma : A meta-analysis [J]. Scientific World Jnurnal, 2013,68:90 - 98.
  • 7Hildesheim A, Wang CP. Genetic predisposition factors anti naso-pharyngeal careinonm risk : A review of epidemiologieal association studies,2000- 2011: Rnsetta Stone for NPC: genetics, viral infection,and other envirnnmental factors[ J ]. Seminars Cancer Biol, 2012,22:107 - 116.
  • 8Alajez NM, Shi W, Hut AB, et al. Enhancer of Zeste homolog 2 (EZH2) is overexpressed in recurrent nasopharyngeal carcinoma and is regulated by miR -26a, miR - 101 , and miR - 98 [ J ]. Cell Death & Disease,2010 : 1 : e85.
  • 9Lee SW, Chen T J, Lin LC,et al. Overexpression of thymidylate synthetase confers an independent prognostic indicator in nasopharyngeal carcinoma[ J]. Exp Mo1 Pathol,2013 ,95 :83 - 90.
  • 10Kim J, Jeong D, Nam J, et al. MicroRNA - 124 rcgulatcs glucocor-ticoid sensitivity by targeting phosphodicstcrase 4B in diffuse large B cell lymphoma[ J]. Gene,2015,558 : 173 - 180.

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