舍曲林联合家庭疗法治疗青少年焦虑障碍的疗效

Efficacy of Sertraline Combined with Family Therapy in the Treatment of Adolescent Anxiety Disorder

目的：观察舍曲林联合家庭疗法治疗青少年焦虑障碍的疗效。方法：40例青少年焦虑障碍的患者,根据自愿原则分别采用舍曲林治疗20例（对照组）,舍曲林联合家庭治疗20例（家庭组）。治疗前后予以汉密尔顿焦虑（HAMA）及生活满意度评定量表（LSR）测定,治疗4周评价疗效。结果：对照组及家庭组治疗前后HAMA、LSR均有非常显著差异（t=12.46,9.70,-5.14,-9.18;P〈0.01）。治疗结束两组药物剂量有显著差异（t=2.200,P=0.03）;治疗结束LSR评分家庭组优于对照组（t=-2.39,P〈0.05）;药物不良反应思睡、口干两组比较有统计学差异（Fisher精确检验P=0.02、0.03）。结论：舍曲林联合家庭疗法以及单独采用舍曲林疗法对青少年焦虑治疗均有效。联合治疗临床效果更好。

Objective：To observe the efficacy of sertraline combined with family therapy in the treatment of anxiety disorder in adolescents.Methods：A total of 40 adolescents with anxiety disorder were treated with sertraline（20 cases）and sertraline combined with family therapy（20 cases）.Hamilton anxiety（HAMA）and life satisfaction rating scale（LSR）were measured before and after treatment,and the efficacy was evaluated after 4 weeks of treatment.Results：There were significant differences in HAMA and LSR before and after treatment in control group and family group（t=12.46,9.70,-5.14,-9.18;P〈0.001）.There was a significant difference in the dose of the two groups at the end of the treatment（t=2.200,P〈0.05）;At the end of the treatment,the LSR score was better in the family group than the control group（t=-2.39,P〈0.05）;There was a statistical difference between the two groups of adverse drug reactions（P〈0.05）.Conclusion：Sertraline combined with family therapy and sertraline alone are effective in the treatment of adolescent anxiety.Combined treatment of clinical effect is better.