帕罗西汀对轻中度血管性痴呆患者认知功能的影响

Effect of Paroxetine on Cognitive Function in Patients with Mild to Moderate Vascular Dementia

目的：探讨帕罗西汀对轻中度血管性痴呆患者认知功能的影响。方法：选取2014年9月-2017年4月在我院门诊就诊及住院的轻中度血管性痴呆患者62例,将患者随机分为实验组和对照组各31例,对照组应用改善脑循环的药物,实验组在对照组用药的基础上加用帕罗西汀10mg-20mg/d。在患者入组时（基线期）和12周末进行疗效评价,采用简易精神状态检查（MMSE）、画钟试验（CDT）、日常生活能力量表（activity of daily living scale,ADL）来评估患者的认知功能及日常生活能力。用副反应量表（Treatment Emergent Symptom Scale,TESS）评估用药期间的不良反应,安全性检查包括每3~5周评估生命体征和在基线及研究期间、终点进行实验室检查。结果：入组时MMSE、ADL、CDT评分结果两组间比较差异无统计学意义（P〉0.05）。治疗12周后,MMSE、ADL、CDT评分结果两组间比较,与对照组相比,实验组改善更明显,差异有统计学意义（t=5.12,-2.95,5.07;P〈0.01）。结论：帕罗西汀对轻中度血管性痴呆患者的认知功能有明显的改善作用。

Objective：To treat patients with vascular dementia with paroxetine to observe the effect on cognitive function.Methods：62 patients with mild to moderate vascular dementia were enrolled in our hospital from September2014 to April 2017.Patients were randomly divided into observation group and control group.There were 31 cases in each group.The control group used drugs to improve the cerebral circulation.In the experimental group,paroxetine 10 mg-20 mg/d was added to the control group.The patients＇ cognitive function and daily living ability were evaluated by simple mental state examination（MMSE）,clock drawing test（CDT）,and daily living capacity scale（activity of daily living scale,ADL）at the time of patient entry（baseline）and 12 weekend.Treatment Emergent Symptom Scale（TESS）was used to assess the adverse reactions during drug use.Safety tests included assessment of vital signs every 3~5 weeks and laboratory tests at the baseline and during the study.Results：The scores of MMSE,ADL and CDT in the two groups were not statistically significant different（P〈0.05）.After 12 weeks of treatment,the results of MMSE,ADL and CDT scores between the two groups were significant different（t=5.12,-2.95,5.07;P〈0.01）.Compared with the control group,the improvement of the experimental group was more obvious.Conclusion：Paroxetine can improve the cognitive function of vascular dementia.