血清肠型脂肪酸结合蛋白水平对小肠外伤手术预后的评估价值

Value of Serum Intestinal-fatty Acid Binding Protein level in the Estimating the Prognosis Following the Surgery for Small Intestine Trauma

为探讨血清肠型脂肪酸结合蛋白(I-FABP)水平在小肠外伤手术患者预后评估中应用价值,选取2017年2月至2018年3月于我院行手术治疗的76例小肠外伤患者作为研究对象,根据患者术前I-FABP水平分为A组(I-FABP水平≥300ng/mL,27例)和B组(I-FABP水平<300 ng/mL,49例),比较2组患者一般资料、术后胃肠功能恢复情况、实验室指标,分析I-FABP水平与患者手术预后的相关性。结果显示,2组患者性别构成、年龄、外伤类型及合并多发伤情况比较差异均无统计学意义,P>0.05; A组患者合并肠系膜损伤、休克及行小肠切除吻合术比例明显高于B组,P <0.05。A组患者白细胞计数(WBC)、C反应蛋白(CRP)、降钙素原(PCT)及胃肠道症状评分均高于B组,P<0.05。A组患者肛门排气时间、进食时间、住院时间均明显长于B组,P <0.05。I-FABP水平与小肠外伤手术患者CRP、PCT、胃肠道症状评分、肛门排气时间、进食时间、住院时间呈正相关。结果表明,I-FABP在小肠外伤手术患者预后中具有一定评估价值,检测I-FABP水平可反映小肠外伤手术患者病情严重程度及预后。

To investigate the value of serum intestinal-fatty acid binding protein（I-FABP） level for estima- ting the prognosis after the surgery for small intestine trauma, 76 cases of this trauma who admitted and had received surgery in author＇s hospital（2017-02--2018-03） were divided into group A（I-FABP level 9300 ng/mL, n =27） and group B（the level 〈300 ng/mL, n =49）,then both group＇s ordinary materials,post- operative recovered status of gastro-intestinal function, Lab. examinated indexes were compared so as to analyse the relativity of I-FABP level and patients＂ prognosis. As results, in gender, age, trauma type, and multi-complicated trauma there was no statistical difference between the two groups（ P 〉0.05）;but in complicated mesentery trauma, shock and the ratio of resection ＆ anastomosis for small intestine,in WBC count,CRP, PCT and gastro-intestinal symptom＇s score,and in the time to pass flatus, eating, and hospital stay group A was respectively higher,higher, and longer than group B（all, P 〈0.05）;and these indexes were positive correlated with I-FABP level proportionally（except for WBC conts）. Results show that I- FABP level has certain value for estimating patients prognosis, so, detecting the levels can reflex patient＇s condition severy and prognosis.