盐酸普拉克索与丁苯酞软胶囊对帕金森患者情绪及血浆Hcy水平的影响

Influence of pramipexole dihydrochloride and butylphthalide on emotion and Hcy in patients with Parkinson＇s disease

目的 探讨盐酸普拉克索与丁苯酞软胶囊对帕金森患者情绪及血浆Hcy水平的影响.方法 选取110例帕金森患者进行研究,按随机数字表法将其分为研究组与对照组,对照组采用盐酸普拉克索治疗,研究组在此基础上加用丁苯酞软胶囊治疗,治疗后比较两组患者治疗效果、情绪、血浆同型半胱氨酸水平、认知功能、统一帕金森病评定量表（UPRDS）评分.结果 研究组治疗总有效率高于对照组,差异有统计学意义（P＜0.05）.治疗后,两组,汉密顿焦虑抑郁量表（HAMD）评分均降低,简易精神状态量表（MMSE）评分均增高,与治疗前比较,差异有统计学意义（均P＜0.05）.治疗后,研究组HAMD量表评分低于对照组,MMSE量表评分高于对照组,差异有统计学意义（均P＜0.05）.治疗后,两组UPRDS评分与血浆Hcy水平均较治疗前下降,差异有统计学意义（均P＜0.05）.治疗后,研究组UPRDS评分与血浆Hcy水平均低于对照组,差异有统计学意义（均P＜0.05）.结论 盐酸普拉克索联合丁苯酞软胶囊可有效改善帕金森患者血浆Hcy水平、情绪及认知功能,疗效优于单独应用盐酸普拉克索.

Objective To investigate the influence of pramipexole dihydrochloride and butylphthalide on emotion and Hcy in patients with Parkinson＇s disease.Methods 104 patients with Parkinson＇s disease were chosen to research,and were divided into a control group and a research group randomly.The control group were treated with pramipexole dihydrochloride,and the research group with pramipexole dihydrochloride and butylphthalide.After the treatment,the clinical effects,Hcy,cognition function,and UPRDS were compared between the two group.Results The total effective rate was higher in the research group than in the control group,with a statistical difference （P 〈 0.05）.After the treatment,the HAMD scale scores of the two groups decreased,and the MMSE scale scores increased,with statistical differences from those before the treatrnent （P 〈 0.05）.After the treatment,the HAMD score was lower and the MMSE scale score was higher in the research group than in the control group,with statistical differences （P 〈 0.05）.After the treatment,the UPRDS score and plasma Hcy level of the two groups decreased,with statistical differences from those before the treatment （P 〈 0.05）.After the treatment,the UPRDS score and plasma Hcy level were lower in the research group than in the control group,with statistical differences （P 〈 0.05）.Conclusion Pramipexole dihydrochloride combined with butylphthalide for patients with Parkinson＇s disease can effectively improve the emotion,Hcy,and cognition function,and its clinical effect is better than pramipexole dihydrochloride.