丹参川芎嗪注射液联合噻托溴铵粉吸入剂治疗慢性阻塞性肺疾病的疗效观察

Salviae miltiorrhizae and ligustrazine injection combined with tiotropium bromide in treatment of chronic obstructive pulmonary disease

目的 探讨丹参川芎嗪注射液联合噻托溴铵粉吸入剂治疗稳定期慢性阻塞性肺疾病的临床疗效.方法 选取本院2015年1月至2017年5月收治的110例稳定期慢性阻塞性肺疾病患者进行研究,按随机数字表法将其分为研究组与对照组,各55例.两组患者均给予基础治疗,对照组患者加用噻托溴铵粉吸入剂治疗,研究组在对照组基础上加用丹参川芎嗪注射液治疗;治疗后,两组患者治疗效果、肺功能及不良反应发生情况比较.结果 研究组患者治愈率18.18％及显效率67.27％均高于对照组,有效率14.54％低于对照组,差异均有统计学意义（均P＜0.05）;但两组患者无效率及总有效率比较,差异均无统计学意义（均P＞ 0.05）;治疗前,两组患者肺功能指标比较,差异无统计学意义（P＞0.05）;治疗后,研究组患者肺功能指标优于对照组,差异有统计学意义（P＜0.05）;两组患者不良反应发生率比较,差异无统计学意义（P＞0.05）.结论 丹参川芎嗪注射液联合噻托溴铵粉吸入剂可有效改善稳定期慢性阻塞性肺疾病患者肺功能,疗效及安全性较好,值得在临床推广.

Objective To investigate the clinical effect of salviae miltiorrhizae and ligustrazine injection combined with tiotropium bromide in the treatment of chronic obstructive pulmonary disease.Methods 110 patients with chronic obstructive pulmonary disease treated at our hospital from January,2015 to May,2017 were chosen as experimental subjects,and were divided into a control group and a research group,55 for each group.Both groups were routinely treated;in addition,the control group were treated with tiotropium bromide,and research group with tiotropium bromide and salviae miltiorrhizae and ligustrazine injection.After the treatment,the clinical effects,pulmonary function,blood gas indexes,and adverse reactions were compared between two group.Results The cured rate was 18.18%,the excellence rate 67.27%,and the effective rate was 14.54% in the research group,which were better than those in the control group,with statistical differences （P 〈 0.05）.However,there were no statistical differences in the ineffectiveness rate and total efficacy between the two groups of （P 〉 0.05）.There were no statistical differences in pulmonary function indicators between the two groups before the treatment （P 〉 0.05）.After the treatment,the pulmonary function indicators were better in the research group than in the control group,with statistical differences （P 〈 0.05）.There was no statistical differences in the incidence of adverse reactions between the two groups （P 〉 0.05）.Conclusion Salviae miltiorrhizae and ligustrazine injection combined with tiotropium bromide in the treatment of chronic obstructive pulmonary disease is effective and safe and can improve the patients＇ pulmonary function,so it is worth being clinically generalized.