来曲唑治疗乳腺癌致结膜炎1例并文献复习

Conjunctivitis caused by letrozole in the treatment of breast cancer： a case report and literature review

目的提高对来曲唑所致眼不良反应的认识。方法报道本院1例应用来曲唑引起结膜炎的病例，同时检索国内外相关文献，总结来曲唑引发的眼部疾病并探讨其发生机制。结果患者应用来曲唑3d后出现结膜炎，停药并经滴眼剂对症治疗后好转。文献检索尚无相关中文文献，英文文献3篇，法语文献1篇。来曲唑可导致黄斑水肿、睑缘炎、泪液分泌障碍、角膜炎和结膜损伤等眼部症状；但也有1例眼球内陷患者使用后眼眶脂肪再生、容积恢复。结论来曲唑引发的眼部不良反应虽然少见，但临床使用时需关注其发生的可能，早期发现并及时停药一般可以逆转。

Objective To improve the recognition of ocular adverse reactions caused by letrozole. Methods A case of conjunctivitis caused by letrozole at our hospital was reported; relevant domestic and abroad literatures were retrieved; and the ocular diseases caused by letrozole were summarized and the mechanism of its occurrence was discussed. Results Conjunctivitis occurred 3 days after letrozole treatment, and the eyes recovered after the withdrawal of letrozole and symptomatic treatment with eye drops. No relevant Chinese literatures had been found, and 3 English and 1 French literatures were found. Letrozole could lead to ocular symptoms, such as macular edema, blepharitis, tear secretion disorder, keratitis, and conjunctival injury, but there was also a case of intraorbital fat regeneration and volume recovery in the patient with endophthalmus. Conclusion Ocular adverse reaction induced by letrozole is rare; but it is necessary to pay attention to; and early detection and timely withdrawal can reverse it.